ro 22-0654 profile

Ro 22-0654: inhibits lipid synthesis [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	133753
SCHEMBL ID	3199571
MeSH ID	M0123796

Synonyms (14)

Synonym
3-thiophenecarboxylic acid, 4-amino-5-ethyl-, methyl ester
2mm80kqn4j ,
ro-22-0654
unii-2mm80kqn4j
ro 22-0654
4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester
81741-99-3
methyl 4-amino-5-ethyl-3-thiophenecarboxylate
methyl 4-amino-5-ethylthiophene-3-carboxylate
SCHEMBL3199571
DTXSID50231307
amino-5-ethyl-3-thiophene-carboxylic acid methyl ester, 4-
STARBLD0002383
AKOS040749321

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" In rats dosed intra-duodenally with I (50 mg/kg), little I was found in the systemic circulation (less than 2 micrograms/ml) but high concentrations (26 micrograms/ml) were present at five minutes in portal plasma."	( Metabolism of the anti-obesity agent, 4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride, in rats and dogs. Baggiolini, E; Bekersky, I; Leinweber, FJ; Loh, AC; Sasso, GJ; Szuna, AJ; Triscari, J; Williams, TH, 1987)	0.27

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.15 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (12.50%)	5.53%
Reviews	1 (12.50%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (75.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	1.96	1	0	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	5.95	8	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
4-(3-(bis(beta-hydroxyphenethyl)amino)butyl)benzamide 4-(3-(bis(beta-hydroxyphenethyl)amino)butyl)benzamide: structure given in first source; RN given is for parent cpd	3.35	1	1
brl 26830a BRL 26830A: structure given in first source	3.35	1	1

Condition	Indicated	Relationship Strength	Studies	Trials
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	0	10.18	4	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	0	1.96	1	0

ro 22-0654

Description