Compounds > phosphonothrixin
Page last updated: 2024-11-12

phosphonothrixin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

phosphonothrixin: isolated from Saccharothrix sp. ST-888; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10631801
SCHEMBL ID9196546
MeSH IDM0254932

Synonyms (4)

Synonym
SCHEMBL9196546
phosphonothrixin
2-hydroxy-2-hydroxymethyl-3-oxobutylphosphonic acid
[2-hydroxy-2-(hydroxymethyl)-3-oxobutyl]phosphonic acid

Research Excerpts

Overview

Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. It has an unusual, branched carbon skeleton.

ExcerptReferenceRelevance
"(S)-Phosphonothrixin is a phosphonate natural product produced by Saccharothrix sp. "( Enantioselective total syntheses of (S)-phosphonothrixin and unexpected cyclic derivative (S)-cyclic phosphonothrixin via enzymatic resolution.
Matsushima, Y; Nakamura, K, 2023)		1.74
"Phosphonothrixin is an herbicidal phosphonate natural product with an unusual, branched carbon skeleton. "( A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria.
Bown, L; Cui, J; Giurgiu, C; Goettge, MN; Hirota, R; Ju, KS; Krist, DT; Metcalf, WW; van der Donk, WA; Zhu, L, 2023)		2.58
"Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. "( Phosphonothrixin, a novel herbicidal antibiotic produced by Saccharothrix sp. ST-888. II. Structure determination.
Kimura, T; Nakamura, K; Takahashi, E, 1995)		3.18
"Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. "( Total synthesis of (+/-)-phosphonothrixin, a novel herbicidal antibiotic containing C-P bond.
Kanno, H; Kimura, T; Nakamura, K; Takahashi, E, 1995)		2.04
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's0 (0.00)29.6817
2010's1 (14.29)24.3611
2020's3 (42.86)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.34 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phosphoenolpyruvate
Phosphoenolpyruvate: A monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in GLYCOLYSIS; GLUCONEOGENESIS; and other pathways.. phosphoenolpyruvate : A monocarboxylic acid anion resuting from selective deprotonation of the carboxy group of phosphoenolpyruvic acid.. phosphoenolpyruvic acid : A monocarboxylic acid that is acrylic acid substituted by a phosphonooxy group at position 2. It is a metabolic intermediate in pathways like glycolysis and gluconeogenesis.		2.4110carboxyalkyl phosphate;
monocarboxylic acid		fundamental metabolite
thiamine pyrophosphate
Thiamine Pyrophosphate: The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.. thiamine(1+) diphosphate chloride : An organic chloride salt of thiamine(1+) diphosphate.		2.4110organic chloride salt;
vitamin B1
3,4-dihydroxyphenylpyruvic acid
3,4-dihydroxyphenylpyruvic acid: metabolite of L-dopa; RN given refers to unlabeled parent cpd. 3,4-dihydroxyphenylpyruvic acid : A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 3,4-dihydroxyphenyl group.		2.6102-oxo monocarboxylic acidmetabolite
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.		3.4470divalent inorganic anion;
phosphite ion
ConditionIndicatedRelationship StrengthStudiesTrials