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ly2605541

Description

LY2605541: an insulin lispro analog with polyethylene glycol covalently attached to lysine B28 via a urethane linkage [MeSH]

Cross-References

ID SourceID
PubMed CID168324442
MeSH IDM0592875

Synonyms (1)

Synonym
ly2605541

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (100.00)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials7 (63.64%)5.53%
Reviews2 (18.18%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other2 (18.18%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
lactic acid2-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
2014201410.0medium000010
c-peptide2014201410.0medium100010
insulin glargine2012201410.3high500060
insulin degludec2014201410.0medium000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Autoimmune Diabetes02014201410.0low100020
Body Weight02014201410.0low000010
Chronic Kidney Failure0201620168.0low100010
Diabetes Mellitus, Adult-Onset02012201410.3high500070
Diabetes Mellitus, Type 102014201410.0low100020
Diabetes Mellitus, Type 202012201410.3high500070
Fasting Hypoglycemia02014201410.0medium400040
Hypoglycemia02014201410.0medium400040
Kidney Failure0201620168.0low100010
Kidney Failure, Chronic0201620168.0low100010
Renal Insufficiency0201620168.0low100010
Weight Gain02014201410.0low100010
Weight Loss02014201410.0low100010
Weight Reduction02014201410.0low100010

Pharmacokinetics (3)

ArticleYear
Pharmacokinetics of the Long-Acting Basal Insulin LY2605541 in Subjects With Varying Degrees of Renal Function.
Clinical pharmacology in drug development, , Volume: 5, Issue:3
2016
Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects.
Journal of clinical pharmacology, , Volume: 54, Issue:7
2014
Steady-state pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 dosed once-daily in patients with type 2 diabetes mellitus.
Diabetes, obesity & metabolism, , Volume: 16, Issue:4
2014

Bioavailability (1)

ArticleYear
Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects.
Journal of clinical pharmacology, , Volume: 54, Issue:7
2014

Dosage (2)

ArticleYear
A clinical utility index for selecting an optimal insulin dosing algorithm for LY2605541 in patients with type 2 diabetes pretreated with basal insulin.
Diabetes technology & therapeutics, , Volume: 16, Issue:8
2014
Steady-state pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 dosed once-daily in patients with type 2 diabetes mellitus.
Diabetes, obesity & metabolism, , Volume: 16, Issue:4
2014