Compounds > lhrh, phe(6)-
Page last updated: 2024-11-13

lhrh, phe(6)-

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

LHRH, Phe(6)-: RN given refers to (D)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25079034
CHEMBL ID3249402
SCHEMBL ID11678163
MeSH IDM0106158

Synonyms (10)

Synonym
gonavet
6-phe-lhrh
lhrh, phenylalanine(6)-
lhrh, phe(6)-
57521-78-5
d-phe(6)-gnrh
gnrh, phe(6)-
CHEMBL3249402
SCHEMBL11678163
DTXSID50206131
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1145199Induction of FSH release in ovariectomized estrogen/progesterone-treated rat at 100 ng, sc measured after 15 mins to 60 hrs post dose by RIA relative to LH-RH1976Journal of medicinal chemistry, Mar, Volume: 19, Issue:3
Analogs of luteinizing hormone-releasing hormone with increased biological activity produced by D-amino acid substitutions in position 6.
AID1136745Ovulation-inducing activity in androgen-sterilized constant-estrus rat at 0.01 ug, iv1978Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
Synthesis and biological activity of highly active alpha-aza analogues of luliberin.
AID1145197Induction of luteinizing hormone release in ovariectomized estrogen/progesterone-treated rat at 100 ng, sc measured after 15 mins to 60 hrs post dose by RIA relative to LH-RH1976Journal of medicinal chemistry, Mar, Volume: 19, Issue:3
Analogs of luteinizing hormone-releasing hormone with increased biological activity produced by D-amino acid substitutions in position 6.
AID1136743Ovulation-inducing activity in androgen-sterilized constant-estrus rat at 0.005 ug, iv1978Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
Synthesis and biological activity of highly active alpha-aza analogues of luliberin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.17 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
buserelin
Buserelin: A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.		1.9510oligopeptide
gonadotropin-releasing hormone
relisorm L: Gonadotropin-Releasing Hormone analog. gonadorelin : A ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence.		1.9510oligopeptide;
peptide hormone		gonadotropin releasing hormone agonist
leuprolide
Leuprolide: A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.. leuprolide : An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.		1.9510oligopeptideanti-estrogen;
antineoplastic agent;
gonadotropin releasing hormone agonist
deslorelin
deslorelin: Ovuplant is tradename for a short-term-release implant containing deslorelin acetate; RN given refers to D-isomer; RN for cpd without isomeric designation not avail 12/90		1.9510oligopeptide
ovurelin
ovurelin: GnRH agonist		1.9510
ConditionIndicatedRelationship StrengthStudiesTrials
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.420
Abdominal Cryptorchidism
[description not available]		01.9910
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9910