Page last updated: 2024-11-06
fluoran
Description
Fluoran is a colorless, crystalline compound that serves as a key intermediate in the synthesis of various fluorescent dyes. Its synthesis typically involves the condensation of phthalic anhydride with resorcinol under acidic conditions. Fluoran itself exhibits weak fluorescence, but its derivatives, such as fluorescein and rhodamine, are highly fluorescent and widely used in applications such as microscopy, flow cytometry, and bioimaging. The unique fluorescence properties of these derivatives arise from the presence of the xanthene ring system and the ability to form resonance structures upon excitation with light. Fluoran derivatives are studied for their potential in medical diagnostics, environmental monitoring, and drug delivery. The study of fluoran and its derivatives is driven by their ability to emit light upon excitation, making them valuable tools for visualization and analysis in various fields.'
fluoran: fluorescein is 3,6-dihydroxyfluoran; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 68994 |
| CHEMBL ID | 2005897 |
| CHEBI ID | 37915 |
| SCHEMBL ID | 77954 |
| MeSH ID | M0081502 |
Synonyms (23)
| Synonym |
|---|
| nsc629162 |
| nsc-629162 |
| spiro[isobenzofuran-3,9'-xanthene]-1-one |
| spiro[isobenzofuran-1(3h),9'-[9h]xanthen]-3-one |
| NCI60_009473 |
| spiro(isobenzofuran-1(3h),9'-xanthen)-3-one |
| spiro(isobenzofuran-1(3h),9'-(9h)xanthen)-3-one |
| 3h-spiro[2-benzofuran-1,9'-xanthen]-3-one |
| 596-24-7 |
| fluoran |
| CHEBI:37915 , |
| spiro[2-benzofuran-3,9'-xanthene]-1-one |
| unii-c8a6lhh76w |
| c8a6lhh76w , |
| einecs 209-880-2 |
| SCHEMBL77954 |
| CHEMBL2005897 |
| FWQHNLCNFPYBCA-UHFFFAOYSA-N |
| xanthylium, 9-(o-carboxyphenyl)-, hydroxide, inner salt |
| benzoic acid, 2-(9-hydroxy-9h-xanthen-9-yl)-, .gamma.-lactone |
| xanthylium, 9-(2-carboxyphenyl)-, hydroxide, inner salt |
| DTXSID50208276 |
| Q5462802 |
Drug Classes (3)
| Class | Description |
|---|
| oxaspiro compound | A spiro compound in which at least one of the cyclic components is an oxygen heterocyle. |
| 2-benzofurans | |
| xanthenes | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 52.36
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 52.36 (24.57) | | Research Supply Index | 2.08 (2.92) | | Research Growth Index | 4.88 (4.65) | | Search Engine Demand Index | 76.22 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |