| Assay ID | Title | Year | Journal | Article |
|---|
| AID130807 | Antitumor activity against ip implanted syngeneic P388 leukemia in mouse after ip administration of 5 mg/kg for 5 days expressed as increase in mean life span | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and antitumor activity of quaternary ellipticine glycosides, a series of novel and highly active antitumor agents. |
| AID98930 | In vitro cytotoxicity against L1210 (murine leukemia) cells. | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazole-1-N- [(dialkylamino)alkyl]carboxamides, a new promising series of antitumor olivacine derivatives. |
| AID235002 | TGI was measured In vitro as the ratio of the mean activity for all non-CNS tumor cell lines over the mean activity of the CNS tumor subpanel (eight cell lines) | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Design, synthesis, and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents. |
| AID91675 | GI50 was given In vitro as +50% percent growth (PG), measured as concentration of compound required to inhibit disease oriented human tumor cell line panels; Value ranges from 0.02->100 | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Design, synthesis, and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents. |
| AID54470 | Binding affinity towards calf thymus DNA, at pH 5 | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
| Synthesis of 11H-pyridocarbazoles and derivatives. Comparison of their DNA binding and antitumor activity with those of 6H- and 7H-pyridocarbazoles. |
| AID130810 | Antitumor activity against iv implanted L1210 leukemia in mouse after ip administration for 5 days expressed as increase in mean life span; NT=Not tested | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and antitumor activity of quaternary ellipticine glycosides, a series of novel and highly active antitumor agents. |
| AID120914 | Tested for antitumor activity against P388 leukemia when administered intravenously at a optimal dose of 10 mg/kg | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazole-1-N- [(dialkylamino)alkyl]carboxamides, a new promising series of antitumor olivacine derivatives. |
| AID91816 | LC50 was given In vitro as -50% percent growth (PG), measured as concentration of compound required to inhibit disease oriented human tumor cell line panels | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Design, synthesis, and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents. |
| AID228573 | LC50 was measured In vitro as the ratio of the mean activity for all non-CNS tumor cell lines over the mean activity of the CNS tumor subpanel (eight cell lines) | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Design, synthesis, and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents. |
| AID226447 | GI50 was measured In vitro as the ratio of the mean activity for all non-CNS tumor cell lines over the mean activity of the CNS tumor subpanel (eight cell lines) | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Design, synthesis, and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents. |
| AID130795 | Antitumor activity against ip implanted L1210 leukemia in mouse after ip administration of 5 mg/kg for 5 days expressed as increase in mean life span | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and antitumor activity of quaternary ellipticine glycosides, a series of novel and highly active antitumor agents. |
| AID97826 | Dose required to inhibit the cloning efficiency to a factor of 0.37 after 24-h exposure to the drug | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
| Synthesis of 11H-pyridocarbazoles and derivatives. Comparison of their DNA binding and antitumor activity with those of 6H- and 7H-pyridocarbazoles. |
| AID231710 | Ratio between brain tumor full panel [A] and sub panel [B] | 1994 | Journal of medicinal chemistry, Jul-08, Volume: 37, Issue:14
| Anticancer specificity of some ellipticinium salts against human brain tumors in vitro. |
| AID131303 | Effect on ip implanted syngeneic B16 melanoma by ip administration for 5 days at 2.5 mg/kg was measured as increase in mean life span | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and antitumor activity of quaternary ellipticine glycosides, a series of novel and highly active antitumor agents. |
| AID137244 | Inhibition of sc implanted syngeneic colon 38 carcinoma by ip administration at 5 mg/kg on 1, 3, 5, 7, 9 days measured as inhibition ratio | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and antitumor activity of quaternary ellipticine glycosides, a series of novel and highly active antitumor agents. |
| AID120918 | Tested for antitumor activity against P388 leukemia when administered intravenously at a optimal dose of 5 mg/kg | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazole-1-N- [(dialkylamino)alkyl]carboxamides, a new promising series of antitumor olivacine derivatives. |
| AID93940 | Cytotoxicity was determined in vitro in murine leukemia L1210 Cells | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8
| Ribose as the preferential target for the oxidized form of elliptinium acetate in ribonucleos(t)ides. Biological activities of the resulting adducts. |
| AID91956 | TGI was given In vitro as 0% percent growth (PG), measured as concentration of compound required to inhibit disease oriented human tumor cell line panels; Value ranges from 1.35->100 | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Design, synthesis, and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents. |
| AID90126 | Concentration yielding an amount of cellular protein at the end of the incubation that is the same as at the beginning of the incubation in full panel | 1994 | Journal of medicinal chemistry, Jul-08, Volume: 37, Issue:14
| Anticancer specificity of some ellipticinium salts against human brain tumors in vitro. |
| AID235001 | TGI correlation coefficient value of the compound | 1994 | Journal of medicinal chemistry, Jul-08, Volume: 37, Issue:14
| Anticancer specificity of some ellipticinium salts against human brain tumors in vitro. |
| AID90125 | Concentration yielding an amount of cellular protein at the end of the incubation that is the same as at the beginning of the incubation in brain tumor sub panel | 1994 | Journal of medicinal chemistry, Jul-08, Volume: 37, Issue:14
| Anticancer specificity of some ellipticinium salts against human brain tumors in vitro. |
| AID97976 | Inhibitory activity against L1210 cell culture | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
| Synthesis of 11H-pyridocarbazoles and derivatives. Comparison of their DNA binding and antitumor activity with those of 6H- and 7H-pyridocarbazoles. |
| AID43180 | Tested for cytotoxicity against C38 cell lines measured by MAT assay | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazole-1-N- [(dialkylamino)alkyl]carboxamides, a new promising series of antitumor olivacine derivatives. |
| AID130973 | Antitumor activity against iv implanted syngeneic P388 leukemia in mouse after ip administration 5 days expressed as increase in mean life span; NT=Not tested | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and antitumor activity of quaternary ellipticine glycosides, a series of novel and highly active antitumor agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |