Compounds > culicinin d
Page last updated: 2024-11-13

culicinin d

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

culicinin D: an antitumor peptaibol produced by the fungus Culicinomyces clavisporus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44583847
CHEMBL ID502978
MeSH IDM0499644

Synonyms (2)

Synonym
CHEMBL502978
culicinin d

Research Excerpts

Overview

Culicinin D is a 10 amino acid peptaibol containing a rare and synthetically challenging (2S,4S,6R)-AHMOD residue. It exhibits potent antiproliferative activity against MDA-MB-468 cells.

ExcerptReferenceRelevance
"Culicinin D is a 10 amino acid peptaibol containing a rare and synthetically challenging (2S,4S,6R)-AHMOD residue, that exhibits potent antiproliferative activity against MDA-MB-468 cells. "( Synthesis and antiproliferative activity of culicinin D analogues containing simplified AHMOD-based residues.
Abbattista, MR; Brimble, MA; Harris, PWR; Kavianinia, I; Patterson, AV; Smaill, JB; Stubbing, LA, 2019)		2.22
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID376647Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as inhibition of S6K phosphorylation after 16 hrs by Western blot2006Journal of natural products, May, Volume: 69, Issue:5
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
AID376649Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as inhibition of 4EBP1 phosphorylation after 16 hrs by Western blot2006Journal of natural products, May, Volume: 69, Issue:5
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
AID376648Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as inhibition of S6 phosphorylation after 16 hrs by Western blot2006Journal of natural products, May, Volume: 69, Issue:5
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
AID376644Growth inhibition of PTEN deficient human MDA468 cells after 3 days by MTS assay2006Journal of natural products, May, Volume: 69, Issue:5
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
AID376651Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as increase in p27Kip1 level at 0.01 to 0.1 ug/mL after 16 hrs by Western blot2006Journal of natural products, May, Volume: 69, Issue:5
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
AID376650Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as inhibition of cyclin D3 level at 0.01 to 0.1 ug/mL after 16 hrs by Western blot2006Journal of natural products, May, Volume: 69, Issue:5
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
AID376646Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as phosphorylated AKT level at 0.01 to 0.1 ug/mL after 16 hrs by Western blot2006Journal of natural products, May, Volume: 69, Issue:5
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
AID376645Growth inhibition of human MDA435 overexpressing PTEN after 3 days by MTS assay2006Journal of natural products, May, Volume: 69, Issue:5
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.26 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		7.2510alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
emerimicins
Peptaibols: A group of peptides characterized by length of 1-2 dozen residues with a high proportion of them being non-proteinogenic, notably alpha-aminoisobutyric acid (Aib) and isovaline, and have a C-terminal amino alcohol and N terminal alkyl group. They are found in FUNGI and some are ANTI-INFECTIVE AGENTS. They form channels or pores in target organisms. The term is a contraction of peptide-Aib-alcohol.		3.3760
ConditionIndicatedRelationship StrengthStudiesTrials