culicinin D: an antitumor peptaibol produced by the fungus Culicinomyces clavisporus; structure in first source [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 44583847 |
| CHEMBL ID | 502978 |
| MeSH ID | M0499644 |
| Synonym |
|---|
| CHEMBL502978 |
| culicinin d |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID376647 | Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as inhibition of S6K phosphorylation after 16 hrs by Western blot | 2006 | Journal of natural products, May, Volume: 69, Issue:5 ISSN: 0163-3864 | Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252. |
| AID376649 | Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as inhibition of 4EBP1 phosphorylation after 16 hrs by Western blot | 2006 | Journal of natural products, May, Volume: 69, Issue:5 ISSN: 0163-3864 | Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252. |
| AID376648 | Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as inhibition of S6 phosphorylation after 16 hrs by Western blot | 2006 | Journal of natural products, May, Volume: 69, Issue:5 ISSN: 0163-3864 | Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252. |
| AID376644 | Growth inhibition of PTEN deficient human MDA468 cells after 3 days by MTS assay | 2006 | Journal of natural products, May, Volume: 69, Issue:5 ISSN: 0163-3864 | Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252. |
| AID376651 | Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as increase in p27Kip1 level at 0.01 to 0.1 ug/mL after 16 hrs by Western blot | 2006 | Journal of natural products, May, Volume: 69, Issue:5 ISSN: 0163-3864 | Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252. |
| AID376650 | Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as inhibition of cyclin D3 level at 0.01 to 0.1 ug/mL after 16 hrs by Western blot | 2006 | Journal of natural products, May, Volume: 69, Issue:5 ISSN: 0163-3864 | Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252. |
| AID376646 | Effect on PI3K/AKT/mTOR pathway in PTEN deficient human MDA468 cells assessed as phosphorylated AKT level at 0.01 to 0.1 ug/mL after 16 hrs by Western blot | 2006 | Journal of natural products, May, Volume: 69, Issue:5 ISSN: 0163-3864 | Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252. |
| AID376645 | Growth inhibition of human MDA435 overexpressing PTEN after 3 days by MTS assay | 2006 | Journal of natural products, May, Volume: 69, Issue:5 ISSN: 0163-3864 | Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| alanine | alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| emerimicins | 2006 | 2020 | 8.7 | high | 0 | 0 | 0 | 1 | 5 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|