Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. It was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program.
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| "Coibamide A is a highly potent antiproliferative cyclic depsipeptide, which was originally isolated from a Panamanian marine cyanobacterium. " | ( Synthesis and biological evaluation of the [d-MeAla(11)]-epimer of coibamide A.
Fujii, N; Hau, AM; Ishmael, JE; McPhail, KL; Misu, R; Nabika, R; Ohno, H; Oishi, S; Suyama, TL, 2015) | 2.1 |
| "Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. " | ( Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins.
Ishmael, JE; Kawaguchi, S; Kazemi, S; Kellosalo, J; Mattos, DR; McPhail, KL; Oishi, S; Paatero, AO; Paavilainen, VO; Richter, U; Serrill, JD; Thornburg, CC; Tranter, D; Vogel, WK; Wan, X, 2020) | 3.44 |
| "Coibamide A is a potent cancer cell toxin and one of a select group of natural products that inhibit protein entry into the secretory pathway via a direct inhibition of the Sec61 protein translocon. " | ( Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A.
Badr, CE; Dolan, BP; Ishmael, JE; Kawaguchi, S; Kazemi, S; Mattos, DR; McPhail, KL; Moasser, MM; Oishi, S; Paavilainen, VO; Ruiz-Saenz, A; Serrill, JD, 2021) | 2.29 |
| "Coibamide A is a cytotoxic marine natural product that induces mTOR-independent autophagy as an adaptive stress response that precedes cell death." | ( ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A.
Ganley, IG; Humphreys, IR; Ishmael, JE; McPhail, KL; Serrill, JD; Tan, M; Wan, X, 2018) | 1.44 |
| "Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. " | ( Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells.
Ganley, IG; Greenwood, JA; Hau, AM; Ishmael, JE; Löhr, CV; McPhail, KL; Proteau, PJ; Serrill, JD, 2013) | 3.28 |
| "Coibamide A is a highly potent antiproliferative cyclodepsipeptide originally isolated from a Panamanian marine cyanobacterium. " | ( Efficient Synthesis and Stereochemical Revision of Coibamide A.
Fang, L; Pan, Z; Su, W; Wang, W; Wu, C; Yao, G, 2015) | 2.11 |
| "Coibamide A is a cytotoxic lariat depsipeptide isolated from a rare cyanobacterium found within the marine reserve of Coiba National Park, Panama. " | ( Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts.
Alani, AW; Coleman, DJ; Hau, AM; Indra, AK; Ishmael, JE; Jang, HS; McPhail, KL; Serrill, JD; Wan, X, 2016) | 3.32 |
| "Coibamide A (1) is a new, potent antiproliferative depsipeptide which was isolated from a marine Leptolyngbya cyanobacterium collected from the Coiba National Park, Panama. " | ( Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp.
Gerwick, WH; Goeger, DE; Hills, P; Huang, N; McPhail, KL; Medina, RA; Mooberry, SL; Ortega-Barría, E; Romero, LI, 2008) | 3.23 |