coibamide-a has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for coibamide-a and Neoplasms
Article | Year |
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Synthesis and biological evaluation of the [d-MeAla(11)]-epimer of coibamide A.
Coibamide A is a highly potent antiproliferative cyclic depsipeptide, which was originally isolated from a Panamanian marine cyanobacterium. In this study, the synthesis of coibamide A has been investigated using Fmoc-based solid-phase peptide synthesis followed by the cleavage of the resulting linear peptide from the resin and its subsequent macrolactonization. The peptide sequence of the linear coibamide A precursor was constructed on a solid-support following the optimization of the coupling conditions, where numerous coupling agents were evaluated. The macrocyclization of the resulting linear peptide provided the [d-MeAla(11)]-epimer of coibamide A, which exhibited nanomolar cytotoxic activity towards a number of human cancer cell lines. Topics: Antineoplastic Agents; Cell Proliferation; Depsipeptides; Humans; Molecular Structure; Neoplasms; Solid-Phase Synthesis Techniques; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2015 |