Page last updated: 2024-11-08

ambamustine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

ambamustine: tripeptide mustard; cpd not in Chemline 8/1/83; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID178137
CHEMBL ID2104687
SCHEMBL ID62822
MeSH IDM0115271

Synonyms (13)

Synonym
ambamustine
ambamustine [inn]
ethyl (2s)-2-[[(2s)-2-[[(2s)-2-amino-3-(4-fluorophenyl)propanoyl]amino]-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-4-methylsulfanylbutanoate
n-(3-(m-(bis(2-chloroethyl)amino)phenyl)-n-(3-(p-fluorophenyl)-l-alanyl)-l-alanyl)-l-methionine, ethyl ester
ib1h345f24 ,
unii-ib1h345f24
85754-59-2
CHEMBL2104687
SCHEMBL62822
ptt119
3-(p-fluorophenyl)-l-alanyl-3-[m-bis(2-chloroethyl)aminophenyl]-l-alanyl-l-methionine ethyl ester
Q27280647
AKOS040746559

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"119 dosage required to reduce the viable L1210 cell fraction by 50% (TCD50)."( Multiple transport pathways for L1210 cells: uptake of PTT.119, a bifunctional alkylator with carrier amino acids.
Bekesi, JG; Chin, SE; Holland, JF; Scanlon, KJ; Yagi, MJ, 1988
)
0.27
" Dose-response studies failed to demonstrate cross-resistance to the tripeptide by L-PAM resistant cells."( PTT.119, p-F-Phe-m-bis-(2-chloroethyl)amino-L-Phe-Met ethoxy HCl, a new chemotherapeutic agent active against drug-resistant tumor cell lines.
Bekesi, JG; Chin, SE; Holland, JF; Scanlon, KJ; Yagi, MJ, 1985
)
0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-199016 (66.67)18.7374
1990's6 (25.00)18.2507
2000's2 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (3.57%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (96.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]