Compounds > aeg 3482
Page last updated: 2024-09-28

aeg 3482

Description

AEG 3482: an antiapoptotic compound that induces expression of Hsp70; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID698112
CHEMBL ID19231
CHEBI ID114182
SCHEMBL ID2540289
MeSH IDM0499837

Synonyms (39)

Synonym
6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide
HMS3269J11
TIMTEC1_001442
OPREA1_698164
NCGC00167812-02
NCGC00167812-01
CHEBI:114182
HMS1538B12 ,
CHEMBL19231
63735-71-7
BCP9000242
aeg 3482
aeg-3482
unii-7ezf1a283n
imidazo(2,1-b)-1,3,4-thiadiazole-2-sulfonamide, 6-phenyl-
6-phenylimidazo(2,1-b)-1,3,4-thiadiazole-2-sulfonamide
7ezf1a283n ,
BRD-K77634909-001-01-9
CCG-221955
SCHEMBL2540289
6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole-2-sulfonic acid amide
6-phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
AKOS024457221
imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide, 6-phenyl-
Q27195229
DTXSID80213176
aeg 3482, >=98% (hplc)
FT-0736105
HMS3677N15
BCP01890
HMS3413N15
BRD-K77634909-001-02-7
NCGC00167812-06
aeg3482
6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
MS-23975
HY-107599
CS-0028938
E98712

Drug Classes (1)

ClassDescription
imidazolesA five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency33.55210.00798.23321,122.0200AID2546; AID2551
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID50177In vitro inhibition of carbonic anhydrase was determined using enzyme prepared from mouse erythrocytes1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides.
AID226919Anticonvulsant potency in mice relative to compound UK-12130 (ED50 of compound 24/compound)1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides.
AID131557Protective dose against maximal electroshock in mice after peroral administration1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides.
AID26085pKa of the compound was determined1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's4 (40.00)24.3611
2020's3 (30.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
acetazolamide[no description available]medium10monocarboxylic acid amide;
sulfonamide;
thiadiazoles		anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
methazolamide[no description available]medium10sulfonamide;
thiadiazoles
geldanamycin[no description available]medium10
histamine[no description available]low00aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
1-(2-trifluoromethylphenyl)imidazole[no description available]low00imidazoles
1-methylimidazole[no description available]low00imidazoles
4-imidazolemethanol[no description available]low00imidazoles;
primary alcohol
alosetron[no description available]low00imidazoles;
pyridoindole		antiemetic;
gastrointestinal drug;
serotonergic antagonist
azathioprine[no description available]low00aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine		antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug
bay h 4502[no description available]low00biphenyls;
imidazoles
brimonidine[no description available]low00imidazoles;
quinoxaline derivative;
secondary amine		adrenergic agonist;
alpha-adrenergic agonist;
antihypertensive agent
carcinine[no description available]low00beta-alanine derivative;
imidazoles;
monocarboxylic acid amide;
organonitrogen compound;
organooxygen compound		antioxidant;
crustacean metabolite
cgp 20712a[no description available]low00imidazoles
cimetidine[no description available]low00aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
clobenpropit[no description available]low00imidazoles;
imidothiocarbamic ester;
organochlorine compound		H3-receptor antagonist;
H4-receptor agonist
clotrimazole[no description available]low00conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic
dacarbazine[no description available]low00imidazoles;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent;
carcinogenic agent;
prodrug
dimetridazole[no description available]low00C-nitro compound;
imidazoles		antiparasitic agent;
antiprotozoal drug
econazole[no description available]low00dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes
etanidazole[no description available]low00C-nitro compound;
imidazoles;
monocarboxylic acid amide		alkylating agent;
antineoplastic agent;
prodrug;
radiosensitizing agent
flutrimazole[no description available]low00imidazole antifungal drug;
imidazoles;
monofluorobenzenes		EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
tele-methylhistamine[no description available]low00imidazoles;
primary amino compound		human metabolite;
mouse metabolite
alpha-methylhistamine[no description available]low00aralkylamino compound;
imidazoles		animal metabolite;
H3-receptor agonist
imetit[no description available]low00imidazoles;
imidothiocarbamic ester		H3-receptor agonist;
H4-receptor agonist
isoconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
ketoconazole[no description available]low00dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
losartan[no description available]low00biphenylyltetrazole;
imidazoles		angiotensin receptor antagonist;
anti-arrhythmia drug;
antihypertensive agent;
endothelin receptor antagonist
metronidazole[no description available]low00C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
miconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
pd 169316[no description available]low00imidazoles
ronidazole[no description available]low00C-nitro compound;
carbamate ester;
imidazoles		antiparasitic agent;
antiprotozoal drug
sb 220025[no description available]low00aminopyrimidine;
imidazoles;
organofluorine compound;
piperidines		angiogenesis inhibitor;
anti-inflammatory agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
sb 239063[no description available]low00imidazoles
sb 202190[no description available]low00imidazoles;
organofluorine compound;
phenols;
pyridines		apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
sk&f 86002[no description available]low00imidazoles
sulconazole[no description available]low00dichlorobenzene;
imidazoles;
monochlorobenzenes;
organic sulfide
tinidazole[no description available]low00imidazolesantiamoebic agent;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
tioconazole[no description available]low00dichlorobenzene;
ether;
imidazoles;
thiophenes
tizanidine[no description available]low00benzothiadiazole;
imidazoles		alpha-adrenergic agonist;
muscle relaxant
tolazoline[no description available]low00imidazolesalpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent
phentolamine[no description available]low00imidazoles;
phenols;
substituted aniline;
tertiary amino compound		alpha-adrenergic antagonist;
vasodilator agent
azomycin[no description available]low00C-nitro compound;
imidazoles		antitubercular agent
5-methylbenzimidazole[no description available]low00imidazoles
2-methyl-5-nitroimidazole[no description available]low00C-nitro compound;
imidazoles
4-methylimidazole[no description available]low00imidazolescarcinogenic agent;
reaction intermediate
zolimidine[no description available]low00imidazoles
1,2-dimethylimidazole[no description available]low00imidazoles
4-nitroimidazole[no description available]low00C-nitro compound;
imidazoles
metomidate[no description available]low00imidazoles
nimorazole[no description available]low00C-nitro compound;
imidazoles
ipronidazole[no description available]low00C-nitro compound;
imidazoles
ornidazole[no description available]low00C-nitro compound;
imidazoles;
organochlorine compound;
secondary alcohol		antiamoebic agent;
antibacterial drug;
antiinfective agent;
antiprotozoal drug;
antitrichomonal drug;
epitope
1-(trimethylsilyl)-1h-imidazole[no description available]low00imidazoles;
N-silyl compound		chromatographic reagent
lofexidine[no description available]low00aromatic ether;
carboxamidine;
dichlorobenzene;
imidazoles		alpha-adrenergic agonist;
antihypertensive agent
benzonidazole[no description available]low00C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
etomidate[no description available]low00imidazoles
enilconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
4-methylhistamine[no description available]low00aralkylamino compound;
imidazoles		histamine agonist;
metabolite
climbazole[no description available]low00aromatic ether;
hemiaminal ether;
imidazoles;
ketone;
monochlorobenzenes
butoconazole nitrate[no description available]low00aryl sulfide;
conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
organic nitrate salt
butoconazole[no description available]low00aryl sulfide;
conazole antifungal drug;
dichlorobenzene;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes
oxmetidine[no description available]low00benzodioxoles;
imidazoles;
pyrimidone		anti-ulcer drug;
H2-receptor antagonist
fenticonazole[no description available]low00aryl sulfide;
dichlorobenzene;
ether;
imidazoles
alpidem[no description available]low00imidazoles
2-(2-methoxy-4-(methylsulfinyl)phenyl)-1h-imidazo(4,5-c)pyridine[no description available]low00imidazoles
sertaconazole[no description available]low001-benzothiophenes;
dichlorobenzene;
ether;
imidazoles
medetomidine[no description available]low00imidazoles
zoledronic acid[no description available]low001,1-bis(phosphonic acid);
imidazoles		bone density conservation agent
n-acetylhistamine[no description available]low00acetamides;
imidazoles		human metabolite
5-imidazolepropionic acid[no description available]low00imidazoles;
monocarboxylic acid
secnidazole[no description available]low00C-nitro compound;
imidazoles;
secondary alcohol		epitope
nitrefazole[no description available]low00imidazoles
eberconazole[no description available]low00dibenzannulene;
imidazoles;
organochlorine compound
prochloraz[no description available]low00amide fungicide;
aromatic ether;
conazole fungicide;
imidazole fungicide;
imidazoles;
trichlorobenzene;
ureas		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic
methylimidazoleacetic acid[no description available]low00imidazoles;
monocarboxylic acid		GABA agonist;
metabolite
5-(3-methyl-1-triazeno)imidazole-4-carboxamide[no description available]low00imidazoles;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent
1-(3-aminopropyl)imidazole[no description available]low00imidazoles
1-ethyl-2-benzimidazolinone[no description available]low00imidazoles
2-methylhistamine[no description available]low00aralkylamino compound;
imidazoles		histamine agonist;
metabolite
imidazoleacetic acid[no description available]low00imidazoles;
monocarboxylic acid		metabolite;
mouse metabolite
mizoribine[no description available]low00imidazolesanticoronaviral agent
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole[no description available]low00ether;
imidazoles;
monomethoxybenzene		TRP channel blocker
exp3174[no description available]low00biphenylyltetrazole;
imidazoles;
organochlorine compound		metabolite
1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole[no description available]low00C-nitro compound;
imidazoles
histidinal[no description available]low00amino aldehyde;
imidazoles
alpha-methylhistamine[no description available]low00aralkylamino compound;
imidazoles		H3-receptor agonist
tipifarnib[no description available]low00imidazoles;
monochlorobenzenes;
primary amino compound;
quinolone		antineoplastic agent;
apoptosis inducer;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor
histidinol[no description available]low00amino alcohol;
imidazoles		EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitor;
Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite
sb 203580[no description available]low00imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent
fk 1052[no description available]low00imidazoles;
organic heterotricyclic compound		antiemetic;
serotonergic antagonist
cimicoxib[no description available]low00aromatic ether;
imidazoles;
organochlorine compound;
organofluorine compound;
sulfonamide		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug
dabuzalgron[no description available]low00aromatic ether;
imidazoles;
monochlorobenzenes;
sulfonamide		alpha-adrenergic agonist
l 778,123[no description available]low00imidazoles;
monochlorobenzenes;
nitrile;
piperazinone;
tertiary amino compound		antineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor
1-methylpropyl-2-imidazolyl disulfide[no description available]low00imidazoles
2-pentan-3-yl-1H-imidazole[no description available]low00imidazoles
2-(1-adamantyl)imidazole[no description available]low00imidazoles
6-(4-chlorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole[no description available]low00imidazoles
bromodeoxytopsentin[no description available]low00aromatic ketone;
bromoindole;
imidazoles;
indole alkaloid		antibacterial agent;
EC 2.7.1.40 (pyruvate kinase) inhibitor;
marine metabolite
pifithrin-beta[no description available]low00imidazoles
bms 214662[no description available]low00benzenes;
benzodiazepine;
imidazoles;
nitrile;
sulfonamide;
thiophenes		antineoplastic agent;
apoptosis inducer;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor
histidyl-proline diketopiperazine[no description available]low00dipeptide;
homodetic cyclic peptide;
imidazoles;
pyrrolopyrazine		anti-inflammatory agent;
dopamine uptake inhibitor;
human blood serum metabolite
s 1033[no description available]low00(trifluoromethyl)benzenes;
imidazoles;
pyridines;
pyrimidines;
secondary amino compound;
secondary carboxamide		anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor
N-[1-methyl-5-(4-methylphenyl)-2-imidazolyl]-4-oxo-4-(1-piperidinyl)butanamide[no description available]low00imidazoles
2-[[5-(4-fluorophenyl)-1-methyl-2-imidazolyl]thio]-1-(1-piperidinyl)ethanone[no description available]low00imidazoles
2-[[5-(4-chlorophenyl)-1-(2-methoxyethyl)-2-imidazolyl]thio]-N-(thiophen-2-ylmethyl)acetamide[no description available]low00imidazoles
2-(4-chlorophenyl)-3-(2-furanylmethyl)imidazo[4,5-b]quinoxaline[no description available]low00imidazoles
2-(4-methoxyphenyl)-3-propylimidazo[4,5-b]quinoxaline[no description available]low00imidazoles
etomidate[no description available]low00ethyl ester;
imidazoles		intravenous anaesthetic;
sedative
4-(3-amino-2-imidazo[1,2-a]pyridinyl)-2-methoxyphenol[no description available]low00imidazoles
2-(3,4-dichlorophenyl)imidazo[1,2-a]pyrimidine[no description available]low00imidazoles
1-hydroxy-2-phenyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one[no description available]low00imidazoles
3-(4-methoxyphenyl)imidazo[1,5-a]pyridine[no description available]low00imidazoles
N-(2-phenyl-3-imidazo[1,2-a]pyridinyl)carbamic acid methyl ester[no description available]low00imidazoles
N-[3-(6-imidazo[2,1-b]thiazolyl)phenyl]butanamide[no description available]low00imidazoles
N-(6-phenyl-5-imidazo[2,1-b]thiazolyl)benzamide[no description available]low00imidazoles
2-phenyl-3-imidazo[1,2-a]pyridinecarboxaldehyde[no description available]low00imidazoles
N-(2-phenyl-6-imidazo[1,2-a]pyridinyl)acetamide[no description available]low00imidazoles
N,N-dimethylcarbamic acid [4-[6-(trifluoromethyl)-2-imidazo[1,2-a]pyridinyl]phenyl] ester[no description available]low00imidazoles
2-(2-furanyl)-3-(4-methylphenyl)imidazo[4,5-b]quinoxaline[no description available]low00imidazoles
2-[(1,5-diphenyl-2-imidazolyl)thio]-N-(2-furanylmethyl)acetamide[no description available]low00imidazoles
4-chloro-2-[[(1-methyl-5-phenyl-2-imidazolyl)amino]methyl]phenol[no description available]low00imidazoles
5-(4-bromophenyl)-1-methyl-N-(3-pyridinylmethyl)-2-imidazolamine[no description available]low00imidazoles
N'-methyl-N-[1-methyl-5-(4-methylphenyl)-2-imidazolyl]-N'-(phenylmethyl)butanediamide[no description available]low00imidazoles
5-(4-fluorophenyl)sulfonyl-1-(2-methylpropyl)-4-nitro-2-propan-2-ylimidazole[no description available]low00imidazoles
2-(3,5-dinitrophenyl)-3-(2-phenylethyl)imidazo[4,5-b]quinoxaline[no description available]low00imidazoles
2-(4-methylsulfonylphenyl)-6-imidazo[1,2-a]pyridinecarboxylic acid methyl ester[no description available]low00imidazoles
1-[[[1-(6-methyl-2-pyridinyl)-4-imidazolyl]-oxomethyl]amino]-3-phenylthiourea[no description available]low00imidazoles
metiamide[no description available]low00imidazoles
4,5-dichloro-2-methyl-1-(2-phenoxyethyl)imidazole[no description available]low00imidazoles
2-Chloro-6-(1H-imidazol-1-yl)benzonitrile[no description available]low00imidazoles
[1-Benzyl-2-(methylsulfanyl)-1H-imidazol-5-yl]methanol[no description available]low00imidazoles
2-(1-benzyl-1H-imidazol-5-yl)phenol[no description available]low00imidazoles
1-[2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-nitrophenyl]-1H-imidazole[no description available]low00imidazoles
2-[4-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrimidine[no description available]low00imidazoles
6-methyl-2-[4-(1-piperidinylsulfonyl)phenyl]imidazo[1,2-a]pyridine[no description available]low00imidazoles
1-[(4-tert-butylphenyl)methyl]-4-(4-nitrophenyl)imidazole[no description available]low00imidazoles
burimamide[no description available]low00imidazoles
carnidazole[no description available]low00C-nitro compound;
imidazoles
2-methoxy-4-[5-methyl-3-(2-oxolanylmethylamino)-2-imidazo[1,2-a]pyridinyl]phenol[no description available]low00imidazoles
4-[3-(1,3-benzodioxol-5-ylmethylamino)-7-methyl-2-imidazo[1,2-a]pyridinyl]phenol[no description available]low00imidazoles
2-[[5-(4-fluorophenyl)-1-methyl-2-imidazolyl]thio]-1-(2-methyl-2,3-dihydroindol-1-yl)ethanone[no description available]low00imidazoles
N-[3-(diethylamino)propyl]-6-(4-fluorophenyl)-3-methyl-2-imidazo[2,1-b]thiazolecarboxamide[no description available]low00imidazoles
N-(1,3-benzodioxol-5-yl)-3-methyl-6-phenyl-2-imidazo[2,1-b]thiazolecarboxamide[no description available]low00imidazoles
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2-[[1-(3-methylphenyl)-2-imidazolyl]thio]acetamide[no description available]low00imidazoles
4-[[2-(4-methoxyphenyl)-6-imidazo[2,1-b][1,3]benzothiazolyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester[no description available]low00imidazoles
4-[3-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-imidazo[1,2-a]pyrimidinyl]phenol[no description available]low00imidazoles
5-(1,3-benzodioxol-5-yl)-3-[3-(methylthio)phenyl]-1H-imidazol-2-one[no description available]low00imidazoles
2-(2-ethoxyphenyl)-8-oxo-9-phenyl-7H-purine-6-carboxamide[no description available]low00imidazoles
1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole[no description available]low00imidazoles
1-[6-(4-chlorophenyl)-5-imidazo[2,1-b]thiazolyl]-N-[(3,4-dichlorophenyl)methoxy]methanimine[no description available]low00imidazoles
1-[4-(2-chlorophenoxy)butyl]imidazole[no description available]low00aromatic ether;
imidazoles;
monochlorobenzenes
4-[(3-methyl-5-nitro-4-imidazolyl)amino]phenol[no description available]low00C-nitro compound;
imidazoles
4-(4-ethoxyphenyl)-1-(4-methoxyphenyl)-2-(methylthio)imidazole[no description available]low00imidazoles
4-[(7-methyl-2-phenyl-3-imidazo[1,2-a]pyridinyl)methyl]morpholine[no description available]low00imidazoles
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide[no description available]low00benzamides;
benzodioxoles;
imidazoles;
pyridines		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
1-(3,4-dihydro-2H-quinolin-1-yl)-2-[[1-(4-ethoxyphenyl)-2-imidazolyl]thio]ethanone[no description available]low00imidazoles
2-[[1-(3-methoxyphenyl)-2-imidazolyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide[no description available]low00imidazoles
N-(4-tert-butylphenyl)-2-[4-(1-imidazolyl)phenoxy]acetamide[no description available]low00imidazoles
2-[[4-(3,4-dimethylphenyl)-1-phenyl-2-imidazolyl]thio]-N-(1,1-dioxo-3-thiolanyl)acetamide[no description available]low00imidazoles
6-(4-methoxyphenyl)-N,3-dimethyl-2-imidazo[2,1-b]thiazolecarboxamide[no description available]low00imidazoles
eprosartan[no description available]low00dicarboxylic acid;
imidazoles;
thiophenes		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic
neticonazole[no description available]low00aromatic ether;
benzenes;
conazole antifungal drug;
enamine;
imidazole antifungal drug;
imidazoles;
methyl sulfide		antifungal drug;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
2-(2-chlorophenyl)-9-(3-methylphenyl)-8-oxo-7H-purine-6-carboxamide[no description available]low00imidazoles
N-[(3-methyl-6-imidazo[2,1-b]thiazolyl)methyl]-1-propanesulfonamide[no description available]low00imidazoles
oxiconazole[no description available]low00conazole antifungal drug;
dichlorobenzene;
imidazole antifungal drug;
imidazoles;
oxime O-ether		antiinfective agent
3-[(1S)-1-phenylethyl]-4-imidazolecarboxylic acid ethyl ester[no description available]low00imidazoles
d 4476[no description available]low00imidazoles
azanidazole[no description available]low00C-nitro compound;
imidazoles
4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine[no description available]low00imidazoles
N-[5-(2-imidazo[1,2-a]pyrimidinyl)-2-methoxyphenyl]-2-methylpropanamide[no description available]low00imidazoles
4-[3-(3-methylanilino)-2-imidazo[1,2-a]pyrimidinyl]phenol[no description available]low00imidazoles
2-[4-(dimethylamino)phenyl]-N-(4-methylphenyl)-3-imidazo[1,2-a]pyrimidinamine[no description available]low00imidazoles
N-(1,3-benzodioxol-5-yl)-2-(4-methylphenyl)-3-imidazo[1,2-a]pyrazinamine[no description available]low00imidazoles
sb-505124[no description available]low00benzodioxole;
imidazoles;
methylpyridines		TGFbeta receptor antagonist
cyazofamid[no description available]low00imidazole fungicide;
imidazoles;
nitrile;
organochlorine compound;
sulfamides;
sulfonamide fungicide		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor
npi 2358[no description available]low002,5-diketopiperazines;
benzenes;
imidazoles;
olefinic compound		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
microtubule-destabilising agent
l-779,450[no description available]low00imidazoles
chir 99021[no description available]low00aminopyridine;
aminopyrimidine;
cyanopyridine;
diamine;
dichlorobenzene;
imidazoles;
secondary amino compound		EC 2.7.11.26 (tau-protein kinase) inhibitor
4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-N,N-dimethylaniline[no description available]low00imidazoles
eluxadoline[no description available]low00amino acid amide;
benzamides;
imidazoles;
L-phenylalanine derivative;
methoxybenzoic acid		delta-opioid receptor antagonist;
gastrointestinal drug;
kappa-opioid receptor agonist;
mu-opioid receptor agonist
cenicriviroc[no description available]low00aromatic ether;
benzazocine;
diether;
imidazoles;
secondary carboxamide;
sulfoxide		anti-HIV agent;
anti-inflammatory agent;
antirheumatic drug;
chemokine receptor 2 antagonist;
chemokine receptor 5 antagonist
4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3h-imidazol-4-yl)pyrimidin-2-ylamine[no description available]low00aminopyrimidine;
imidazoles;
monofluorobenzenes		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
imidazoleacetic acid ribotide[no description available]low00imidazoles;
monocarboxylic acid;
N-glycosyl compound;
ribose monophosphate
cefpodoxime[no description available]low00imidazoles
sgi 1776[no description available]low00imidazoles
bms-790052[no description available]low00biphenyls;
carbamate ester;
carboxamide;
imidazoles;
valine derivative		antiviral drug;
nonstructural protein 5A inhibitor
9-(3,5-difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile[no description available]low00imidazoles
chir 98014[no description available]low00aminopyrimidine;
C-nitro compound;
diaminopyridine;
dichlorobenzene;
imidazoles;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
hypoglycemic agent;
tau aggregation inhibitor;
Wnt signalling activator
ledipasvir[no description available]low00azaspiro compound;
benzimidazole;
bridged compound;
carbamate ester;
carboxamide;
fluorenes;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organofluorine compound		antiviral drug;
hepatitis C protease inhibitor
gs-5816[no description available]low00carbamate ester;
ether;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organic heteropentacyclic compound;
ring assembly		antiviral drug;
hepatitis C virus nonstructural protein 5A inhibitor
mk-8742[no description available]low00carbamate ester;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organic heterotetracyclic compound;
ring assembly		antiviral drug;
hepatitis C virus nonstructural protein 5A inhibitor;
hepatoprotective agent
sb-590885[no description available]low00aromatic ether;
imidazoles;
ketoxime;
pyridines;
tertiary amino compound
ConditionIndicatedRelationship StrengthStudiesTrials
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Degenerative Diseases, Central Nervous System0low10
Degenerative Diseases, Nervous System0low10
Degenerative Diseases, Neurologic0low10
Degenerative Diseases, Spinal Cord0low10
Degenerative Neurologic Diseases0low10
Degenerative Neurologic Disorders0low10
Disease Models, Animal0low10
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Fever, Zika0low10
Infantile Paralysis0low10
Malaria, Falciparum0low10
Nervous System Degenerative Diseases0low10
Neurodegenerative Diseases0low10
Neurodegenerative Disorders0low10
Neurologic Degenerative Conditions0low10
Neurologic Degenerative Diseases0low10
Neurologic Diseases, Degenerative0low10
Plasmodium falciparum Malaria0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress.
Journal of Alzheimer's disease : JAD, Volume: 22, Issue: 3		2010
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]