aeg-3482 and Neurodegenerative-Diseases

aeg-3482 has been researched along with Neurodegenerative-Diseases* in 1 studies

Other Studies

1 other study(ies) available for aeg-3482 and Neurodegenerative-Diseases

ArticleYear
Targeting HSP90 to halt neurodegeneration.
    Chemistry & biology, 2006, Volume: 13, Issue:2

    Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis .

    Topics: Animals; Enzyme Activation; Enzyme Inhibitors; HSP90 Heat-Shock Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Neurodegenerative Diseases; Neuroprotective Agents; Signal Transduction; Sulfonamides; Thiadiazoles

2006
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