aeg-3482 and Neurodegenerative-Diseases
aeg-3482 has been researched along with Neurodegenerative-Diseases* in 1 studies
Other Studies
1 other study(ies) available for aeg-3482 and Neurodegenerative-Diseases
Article | Year |
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Targeting HSP90 to halt neurodegeneration.
Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis . Topics: Animals; Enzyme Activation; Enzyme Inhibitors; HSP90 Heat-Shock Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Neurodegenerative Diseases; Neuroprotective Agents; Signal Transduction; Sulfonamides; Thiadiazoles | 2006 |