Compounds > 3-Epikatonic acid
Page last updated: 2024-11-12

3-Epikatonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID10434225
CHEMBL ID463266
CHEBI ID186795
SCHEMBL ID15475219

Synonyms (16)

Synonym
CHEMBL463266
epikatonic acid
(2r,4as,6ar,6as,6br,8ar,10s,12ar,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-2-carboxylic acid
3-epikatonic acid
CHEBI:186795
LMPR0106150019
(20r)-3beta-hydroxyolean-12-en-29-oic acid
76035-62-6
SCHEMBL15475219
3-hydroxy-(3beta,20alpha)-olean-12-en-29-oic acid
NCGC00485408-01
AKOS032962425
FS-9015
DTXSID201316985
CS-0017680
HY-N1826

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID357941Cytotoxicity against vincristine-resistant mouse P388 cells2001Journal of natural products, Sep, Volume: 64, Issue:9
New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID357940Cytotoxicity against drug-sensitive mouse P388/S cells2001Journal of natural products, Sep, Volume: 64, Issue:9
New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID357938Immunosuppressant activity in mouse lymphocytes assessed as inhibition of lymphocyte proliferation2001Journal of natural products, Sep, Volume: 64, Issue:9
New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID357943Cytotoxicity against adriamycin-resistant mouse P388 cells2001Journal of natural products, Sep, Volume: 64, Issue:9
New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID467996Cytotoxic activity against human MCF7 cells after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity.
AID467997Cytotoxicity activity against mouse LLC cells after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity.
AID357944Cytotoxicity against adriamycin-resistant mouse P388 cells in presence of adriamycin2001Journal of natural products, Sep, Volume: 64, Issue:9
New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID357942Cytotoxicity against vincristine-resistant mouse P388 cells in presence of vincristine2001Journal of natural products, Sep, Volume: 64, Issue:9
New multiflorane-type triterpenoid acids from Sandoricum indicum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oleanolic acid
[no description available]		2.0510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
doxorubicin hydrochloride
[no description available]		2.0510anthracycline
koetjapic acid
koetjapic acid: antineoplastic from Sandoricum koetjape tree bark; structure in first source		210steroid acid
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		0210
Leukemia, Lymphocytic
[description not available]		0210
Leukemia, Lymphoid
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.		0210
Congenital Zika Syndrome
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510