3-Epikatonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	10434225
CHEMBL ID	463266
CHEBI ID	186795
SCHEMBL ID	15475219

Synonyms (16)

Synonym
CHEMBL463266
epikatonic acid
(2r,4as,6ar,6as,6br,8ar,10s,12ar,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-2-carboxylic acid
3-epikatonic acid
CHEBI:186795
LMPR0106150019
(20r)-3beta-hydroxyolean-12-en-29-oic acid
76035-62-6
SCHEMBL15475219
3-hydroxy-(3beta,20alpha)-olean-12-en-29-oic acid
NCGC00485408-01
AKOS032962425
FS-9015
DTXSID201316985
CS-0017680
HY-N1826

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
triterpenoid	Any terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID357941	Cytotoxicity against vincristine-resistant mouse P388 cells	2001	Journal of natural products, Sep, Volume: 64, Issue:9	New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID357940	Cytotoxicity against drug-sensitive mouse P388/S cells	2001	Journal of natural products, Sep, Volume: 64, Issue:9	New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID357938	Immunosuppressant activity in mouse lymphocytes assessed as inhibition of lymphocyte proliferation	2001	Journal of natural products, Sep, Volume: 64, Issue:9	New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID357943	Cytotoxicity against adriamycin-resistant mouse P388 cells	2001	Journal of natural products, Sep, Volume: 64, Issue:9	New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID467996	Cytotoxic activity against human MCF7 cells after 48 hrs by MTT assay	2009	Journal of natural products, Aug, Volume: 72, Issue:8	Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity.
AID467997	Cytotoxicity activity against mouse LLC cells after 48 hrs by MTT assay	2009	Journal of natural products, Aug, Volume: 72, Issue:8	Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity.
AID357944	Cytotoxicity against adriamycin-resistant mouse P388 cells in presence of adriamycin	2001	Journal of natural products, Sep, Volume: 64, Issue:9	New multiflorane-type triterpenoid acids from Sandoricum indicum.
AID357942	Cytotoxicity against vincristine-resistant mouse P388 cells in presence of vincristine	2001	Journal of natural products, Sep, Volume: 64, Issue:9	New multiflorane-type triterpenoid acids from Sandoricum indicum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	2 (40.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.84 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.63 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
oleanolic acid [no description available]	2.05	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
doxorubicin hydrochloride [no description available]	2.05	1	anthracycline
koetjapic acid koetjapic acid: antineoplastic from Sandoricum koetjape tree bark; structure in first source	2	1	steroid acid

Condition	Relationship Strength	Studies
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	2	1
Leukemia, Lymphocytic [description not available]	2	1
Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	2	1
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

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