3-Epikatonic-acid and Leukemia-P388

Three new 12beta-hydroxymultiflorane triterpenoid acids, sandorinic acids A-C (1-3), were isolated from the stem bark of Sandoricum indicum together with five known triterpenes (4-8). The structures of 1-3 were elucidated by spectral data interpretation. Compounds 1-8 were evaluated for their inhibiting activity against several tumor cell lines and for their effects on lymphocyte proliferation.

Topics: Animals; Antineoplastic Agents, Phytogenic; Chromatography; Chromatography, High Pressure Liquid; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Leukemia P388; Leukemia, Lymphoid; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Meliaceae; Mice; Molecular Structure; Plant Stems; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thailand; Triterpenes; Tumor Cells, Cultured; Vincristine