1,(n2)-ethenoguanine profile

1,(N2)-ethenoguanine: formed from 2-halooxiranes; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1,N(2)-ethenoguanine : A nucleobase analogue obtained by addition of an etheno group across positions 1 and N2 of guanine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	124322
CHEBI ID	134096
SCHEMBL ID	8148622
SCHEMBL ID	1576524
MeSH ID	M0226958

Synonym
1,(n2)-ethenoguanine
1,n(2)-ethenoguanine
56287-13-9
1,n(2)-epsilong
1,4-dihydro-9h-imidazo[1,2-a]purin-9-one
CHEBI:134096
1,4-dihydroimidazo[1,2-a]purin-9-one
1,4-dihydro-9h-imidazo(1,2-a)purin-9-one
9h-imidazo(1,2-a)purin-9-one, 1,4-dihydro-
1,n2-epsilong nucleobase
SCHEMBL8148622
SCHEMBL1576524
DTXSID60204825
epsilong
3,9-dihydro-9-oxo-5h-imidazo[1,2-a]purine

Class	Description
imidazopurine
nucleobase analogue	A molecule that can substitute for a normal nucleobase in nucleic acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (21.43)	18.2507
2000's	8 (57.14)	29.6817
2010's	1 (7.14)	24.3611
2020's	2 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	2.99	4	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
cytosine [no description available]	2.78	3	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
vinyl chloride Vinyl Chloride: A gas that has been used as an aerosol propellant and is the starting material for polyvinyl resins. Toxicity studies have shown various adverse effects, particularly the occurrence of liver neoplasms.. chloroethene : A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group.	2	1	chloroethenes; gas molecular entity; monohaloethene	carcinogenic agent
1-methylguanine [no description available]	2.05	1	methylguanine
1,n(6)-ethenoadenine 1,N(6)-ethenoadenine: biologically active fluorescent derivatives of this cpd potentially valuable in studies concerning interactions between adenine cpds & various enzymes for which they serve as substrates or co-factors; structure	2.99	4	imidazo[2,1-i]purine	mutagen
5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo(1,2-a)purine 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo(1,2-a)purine: derivative of N(2)-(2-oxoethyl)guanine; structure given in first source	2.4	2
n(2),3-ethenoguanine N(2),3-ethenoguanine: formed from 2-halooxiranes. N(2),3-ethenoguanine : A nucleobase analogue obtained by addition of an etheno group across positions N2 and 3 of guanine.	2.42	2	imidazopurine; nucleobase analogue
oligonucleotides [no description available]	2.72	3
deoxyguanosine triphosphate [no description available]	1.99	1	deoxyguanosine phosphate; guanyl deoxyribonucleotide; purine 2'-deoxyribonucleoside 5'-triphosphate	Arabidopsis thaliana metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
guanine [no description available]	4.04	14	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
7-methylguanine 7-methylguanine: RN given refers to unlabeled cpd; structure. 7-methylguanine : A methylguanine that is guanine substituted by a methyl group at position 7. It is a metabolite obtained during the methylation of DNA.. 2-imino-7-methyl-1,2,3,7-tetrahydro-6H-purin-6-one : A 7-methylguanine that is 1,2,3,7-tetrahydro-6H-purin-6-one substituted by an imino group at position 2 and a methyl group at position 7.. 2-amino-7-methyl-7H-purin-6-ol : A 7-methylguanine that is 7H-purine substituted by an amino group at position 2, a methyl group at position 7 and a hydroxy group at position 6.. 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one : A 7-methylguanine that is 1,7-dihydro-6H-purin-6-one substituted by an amino group at position 2 and a methyl group at position 7.	2.05	1	7-methylguanine
3,n(4)-ethanocytosine [no description available]	2.78	3	organic heterobicyclic compound	mutagen

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.41	2	0
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	0	2	1	0

1,(n2)-ethenoguanine

Description

Cross-References

Synonyms (15)

Drug Classes (2)

Research

Studies (14)

Market Indicators

Research Demand Index: 11.85

Study Types