dihydroxycoprostane profile

dihydroxycoprostane: intermediate in bile acid synthesis in the liver; enhance rate of prophyrin synthesis in cultured liver cells by induction of delta-aminolevulinic acid synthetase; RN given refers to (3alpha,5beta,7alpha)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	3080603
CHEBI ID	28047
SCHEMBL ID	1331092
MeSH ID	M0050622

Synonym
3,7-dihydroxycholestane
3,7-dihydroxy-5-cholestane
5alpha-cholestane-3beta,7beta-diol
cholestane-3,7-diol, (3alpha,5beta,7alpha)-
3862-26-8
CHEBI:28047
dihydroxycoprostane
3alpha,7alpha-dihydroxy-5beta-cholestane
5beta-cholestane-3alpha,7alpha-diol
C05452
LMST04030109
SCHEMBL1331092
cholestane-3,7-diol
5b-cholestane-3a,7a-diol
3a,7a-dihydroxy-5b-cholestane
Q27103477
DTXSID00959468

Role	Description
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
mouse metabolite	Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
3alpha-hydroxy steroid	A 3-hydroxy steroid in which the 3-hydroxy substituent is in the alpha-position.
7alpha-hydroxy steroid	A 7-hydroxy steroid in which the hydroxy group at position 7 has an alpha-configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Metabolism	1496	1108
Metabolism of lipids	500	463
Metabolism of steroids	111	135
Bile acid and bile salt metabolism	31	71
Synthesis of bile acids and bile salts	20	68
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	16	44
Bile Acid Biosynthesis	17	61
Congenital Bile Acid Synthesis Defect Type II	17	61
Congenital Bile Acid Synthesis Defect Type III	17	61
Familial Hypercholanemia (FHCA)	17	61
Zellweger Syndrome	17	61
Cerebrotendinous Xanthomatosis (CTX)	17	61
27-Hydroxylase Deficiency	17	61
Disorders of bile acid synthesis and biliary transport	18	40
bile acid biosynthesis, neutral pathway	6	44
Biochemical pathways: part I	0	466

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (57.14)	18.7374
1990's	6 (42.86)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.14%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (92.86%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pipecolic acid pipecolic acid: RN given refers to cpd without isomeric designation. pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.. pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid.	3.09	1	piperidinemonocarboxylic acid
lauric acid dodecanoic acid : A straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.	1.97	1	medium-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; antibacterial agent; plant metabolite
chenodeoxycholic acid Chenodeoxycholic Acid: A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.. chenodeoxycholic acid : A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.. chenodeoxycholate : Conjugate base of chenodeoxycholic acid; major species at pH 7.3.	2.37	2	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human metabolite; mouse metabolite
3,7,12-trihydroxycoprostanic acid [no description available]	1.98	1	12alpha-hydroxy steroid; 3alpha-hydroxy steroid; 7alpha-hydroxy steroid; cholestanoic acid; hydroxy monocarboxylic acid	human metabolite
7 alpha-hydroxy-4-cholesten-3-one 7 alpha-hydroxy-4-cholesten-3-one: structure. 7alpha-hydroxycholest-4-en-3-one : A cholestanoid consisting of a cholesterol core having an oxo group at the 3-position, a C=C bond at the 4,5-position and an alpha-hydroxy group at the 7-position.	2.38	2	3-oxo-Delta(4) steroid; 7alpha-hydroxy steroid; cholestanoid	human metabolite; mouse metabolite
3,7,12-trihydroxycoprostane 3,7,12-trihydroxycoprostane: intermediate in bile acid synthesis in liver; enhances rate of porphyrin synthesis in cultured liver cells by induction of delta-aminolevulinic acid synthetase; RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer; structure	4.32	6	12alpha-hydroxy steroid; 3alpha-hydroxy steroid; 7alpha-hydroxy steroid	human metabolite; mouse metabolite
cholic acid Cholic Acid: A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.. cholic acid : A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.	7.35	2	12alpha-hydroxy steroid; 3alpha-hydroxy steroid; 7alpha-hydroxy steroid; bile acid; C24-steroid; trihydroxy-5beta-cholanic acid	human metabolite; mouse metabolite
3,7-dihydroxycholestan-26-oic acid [no description available]	1.99	1
nadp [no description available]	2.38	2
cholecalciferol Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	1.97	1	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	1.95	1

Condition	Relationship Strength	Studies
Acquired Metabolic Diseases, Brain [description not available]	1.96	1
Lipid Metabolism, Inborn Error [description not available]	1.96	1
Xanthoma [description not available]	1.96	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.98	1
Adrenoleukodystrophy, Autosomal Neonatal Form [description not available]	2.91	1
Peroxisomal Disorders A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.	2.91	1
Alloxan Diabetes [description not available]	1.97	1

dihydroxycoprostane

Description

Cross-References

Synonyms (17)

Roles (2)

Drug Classes (2)

Pathways (16)

Research

Studies (14)

Market Indicators

Research Demand Index: 11.70

Study Types