Page last updated: 2024-12-08

3,7,12-trihydroxycoprostane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,7,12-trihydroxycoprostane: intermediate in bile acid synthesis in liver; enhances rate of porphyrin synthesis in cultured liver cells by induction of delta-aminolevulinic acid synthetase; RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID160520
CHEMBL ID4468145
CHEBI ID16496
SCHEMBL ID2508894
MeSH IDM0054375

Synonyms (25)

Synonym
BIDD:PXR0083
gtpl2803
CHEBI:16496
trihydroxycoprostane
3alpha,7alpha,12alpha-trihydroxycoprostane
C05454
5beta-cholestane-3alpha,7alpha,12alpha-triol
547-96-6
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane
LMST04030035
(3r,5s,7r,8r,9s,10s,12s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-3,7,12-triol
A834338
3,7,12-trihydroxycoprostane
3,7,12-trihydroxycholestane
cholestane-3,7,12-triol
(3alpha,5beta,7alpha,12alpha)-cholestane-3,7,12-triol
gtpl2767
trihydroxycholestane
SCHEMBL2508894
AKOS030240754
CHEMBL4468145
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol
Q28529721
(3r,5s,7r,9s,10s,12s,13r,14s,17r)-10,13-dimethyl-17-((r)-6-methylheptan-2-yl)hexadecahydro-1h-cyclopenta[a]phenanthrene-3,7,12-triol
DTXSID70969998
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
3alpha-hydroxy steroidA 3-hydroxy steroid in which the 3-hydroxy substituent is in the alpha-position.
7alpha-hydroxy steroidA 7-hydroxy steroid in which the hydroxy group at position 7 has an alpha-configuration.
12alpha-hydroxy steroid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (20)

PathwayProteinsCompounds
Metabolism14961108
Metabolism of lipids500463
Metabolism of steroids111135
Bile acid and bile salt metabolism3171
Synthesis of bile acids and bile salts2068
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol1644
Bile Acid Biosynthesis1761
Congenital Bile Acid Synthesis Defect Type II1761
Congenital Bile Acid Synthesis Defect Type III1761
Familial Hypercholanemia (FHCA)1761
Zellweger Syndrome1761
Cerebrotendinous Xanthomatosis (CTX)1761
27-Hydroxylase Deficiency1761
Disease1278231
Diseases of metabolism69121
Metabolic disorders of biological oxidation enzymes647
Defective CYP27A1 causes CTX05
Disorders of bile acid synthesis and biliary transport1840
bile acid biosynthesis, neutral pathway644
Oxysterols derived from cholesterol3831

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1346741Human Pregnane X receptor (1I. Vitamin D receptor-like receptors)2003Proceedings of the National Academy of Sciences of the United States of America, Jan-07, Volume: 100, Issue:1
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
AID1346802Mouse Pregnane X receptor (1I. Vitamin D receptor-like receptors)2003Proceedings of the National Academy of Sciences of the United States of America, Feb-04, Volume: 100, Issue:3
Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-199014 (50.00)18.7374
1990's8 (28.57)18.2507
2000's4 (14.29)29.6817
2010's2 (7.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.69

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.69 (24.57)
Research Supply Index3.40 (2.92)
Research Growth Index4.09 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.69)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (6.90%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (93.10%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]