NAD+- protein-cysteine ADP-ribosyltransferase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]. [PMID:25043379, RHEA:56612]
NAD+-protein-cysteine ADP-ribosyltransferase activity catalyzes the transfer of ADP-ribose from NAD+ to a cysteine residue on a target protein. This reaction involves the cleavage of the nicotinamide moiety from NAD+, leaving the ADP-ribose moiety to be attached to the cysteine residue. This process is known as ADP-ribosylation. ADP-ribosylation can have various effects on target proteins, including altering their activity, localization, and interactions with other proteins. ADP-ribosyltransferases are involved in a wide range of cellular processes, including signal transduction, DNA repair, and immune response. For example, some ADP-ribosyltransferases are involved in the regulation of cellular stress responses, while others play a role in the immune system by modifying the activity of immune cells. The activity of ADP-ribosyltransferases can be regulated by a variety of factors, including post-translational modifications, protein-protein interactions, and the availability of NAD+. Dysregulation of ADP-ribosyltransferase activity can lead to a variety of diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.'
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Proteins (4)
| Protein | Definition | Taxonomy |
|---|---|---|
| Protein mono-ADP-ribosyltransferase PARP11 | A protein mono-ADP-ribosyltransferase PARP11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NR21] | Homo sapiens (human) |
| Protein mono-ADP-ribosyltransferase PARP12 | A protein mono-ADP-ribosyltransferase PARP12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H0J9] | Homo sapiens (human) |
| Protein mono-ADP-ribosyltransferase PARP8 | A protein mono-ADP-ribosyltransferase PARP8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N3A8] | Homo sapiens (human) |
| Protein mono-ADP-ribosyltransferase PARP6 | A protein mono-ADP-ribosyltransferase PARP6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2NL67] | Homo sapiens (human) |
Compounds (10)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| pj-34 | PJ34 : A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. | phenanthridines; secondary carboxamide; tertiary amino compound | angiogenesis inhibitor; anti-inflammatory agent; antiatherosclerotic agent; antineoplastic agent; apoptosis inducer; cardioprotective agent; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; neuroprotective agent |
| 4-Methoxybenzamide | benzamides | ||
| 3,4-dihydro-5-methyl-1(2h)-isoquinolinone | 3,4-dihydro-5-methyl-1(2H)-isoquinolinone: structure given in first source | isoquinolines | |
| 1-oxo-1,2,3,4-tetrahydroisoquinoline | 1-oxo-1,2,3,4-tetrahydroisoquinoline: structure given in first source | ||
| rucaparib | AG14447: Poly(ADP-ribose) polymerase inhibitor; structure in first source | azepinoindole; caprolactams; organofluorine compound; secondary amino compound | antineoplastic agent; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
| veliparib | benzimidazoles | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | |
| olaparib | cyclopropanes; monofluorobenzenes; N-acylpiperazine; phthalazines | antineoplastic agent; apoptosis inducer; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | |
| niraparib | niraparib : A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. niraparib: structure in first source | 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide | antineoplastic agent; apoptosis inducer; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; radiosensitizing agent |
| xav939 | XAV939 : A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group. XAV939: selectively inhibits beta-catenin-mediated transcription; structure in first source | (trifluoromethyl)benzenes; thiopyranopyrimidine | tankyrase inhibitor |
| bmn 673 | talazoparib: inhibits both PARP1 and PARP2; structure in first source |