DNA-(abasic site) binding

Definition

Target type: molecularfunction

Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base. [PMID:23245849]

DNA-(abasic site) binding is a molecular function that describes the interaction of proteins with DNA containing an abasic site. Abasic sites, also known as AP sites, are lesions in DNA where the nitrogenous base has been removed, leaving a sugar residue without a base. These sites are highly mutagenic and can lead to DNA replication errors and other cellular damage. Proteins that bind to abasic sites play a crucial role in DNA repair pathways. They recognize and bind to the abasic site, providing a platform for other repair enzymes to access and process the damaged DNA. Binding to abasic sites often involves specific interactions with the sugar residue of the abasic site and adjacent nucleotides. The proteins involved in abasic site binding often possess specific domains or motifs that are responsible for recognizing and interacting with the damaged DNA. These domains typically contain amino acids that can form hydrogen bonds or electrostatic interactions with the sugar residue and the surrounding nucleotides. The specific binding properties of different abasic site binding proteins can vary depending on the protein's structure, sequence, and the nature of the abasic site. This diversity allows for the recognition and processing of different types of abasic sites and ensures the efficient repair of DNA damage.'
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Proteins (1)

Compounds (17)