S-nitrosoglutathione reductase (NADH) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: S-nitrosoglutathione + NADH + H+ = S-(hydroxysulfenamide)glutathione + NAD+. [PMID:11260719, PMID:27094420, PMID:30795534]

S-nitrosoglutathione reductase (NADH) activity catalyzes the reduction of S-nitrosoglutathione (GSNO) to glutathione (GSH) and nitric oxide (NO). This reaction is important for maintaining cellular redox homeostasis and regulating NO signaling. The enzyme utilizes NADH as a cofactor to transfer electrons to GSNO, resulting in the cleavage of the S-N bond and the release of NO. This activity plays a crucial role in various cellular processes, including: 1) detoxification of reactive nitrogen species, such as GSNO, which can cause oxidative stress and damage cellular components. 2) regulation of NO signaling pathways, as the enzyme can modulate NO levels in cells. 3) control of protein S-nitrosylation, a post-translational modification that regulates protein function. 4) modulation of cellular redox state, as the enzyme contributes to the balance between reduced and oxidized glutathione. 5) regulation of vasodilation and blood pressure, as NO is a potent vasodilator. S-nitrosoglutathione reductase (NADH) activity is a key enzyme in the cellular response to oxidative stress and NO signaling, and its dysregulation is implicated in various diseases.'
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Proteins (1)

Compounds (12)