phosphatidylinositol-4-phosphate binding

Definition

Target type: molecularfunction

Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. [GOC:bf, GOC:mah]

Phosphatidylinositol-4-phosphate (PI4P) binding is a molecular function that describes the interaction of proteins with the phospholipid PI4P. This interaction plays a crucial role in various cellular processes, including:

- **Membrane trafficking:** PI4P acts as a signaling molecule that recruits specific proteins to particular membrane compartments, facilitating vesicle formation, transport, and fusion. For instance, PI4P is enriched in the Golgi apparatus and plays a key role in the recruitment of coat proteins involved in protein sorting and packaging.
- **Signal transduction:** PI4P can act as a second messenger, modulating the activity of downstream signaling pathways. It can bind to and activate specific enzymes, such as phospholipases, kinases, and GTPases, ultimately influencing cellular responses to stimuli.
- **Cytoskeleton organization:** PI4P interacts with proteins involved in the regulation of the actin cytoskeleton, contributing to cell morphology, migration, and division.
- **Nuclear processes:** PI4P is found in the nucleus and is involved in nuclear envelope organization and chromatin remodeling.

The binding of PI4P to proteins is typically mediated by specific domains, such as the pleckstrin homology (PH) domain, the FYVE domain, and the PX domain. These domains recognize and bind to the head group of PI4P, leading to the recruitment and activation of downstream signaling pathways.

The specific role of PI4P binding varies depending on the protein involved and the cellular context. However, its ability to regulate membrane trafficking, signal transduction, cytoskeleton organization, and nuclear processes highlights its importance in maintaining cellular function and homeostasis.'
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Proteins (5)

Compounds (18)