Page last updated: 2024-10-24

N6-methyl-AMP deaminase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate. [PMID:29884623, RHEA:16001]

N6-methyl-AMP deaminase activity is an enzymatic activity that catalyzes the deamination of N6-methyladenosine 5'-monophosphate (N6-methyl-AMP) to N6-methylinosine 5'-monophosphate (N6-methyl-IMP). This reaction involves the removal of an amino group from the N6 position of adenine in the N6-methyl-AMP molecule, resulting in the formation of a double bond between the N6 and C6 positions of the purine ring. The enzyme responsible for this activity is known as N6-methyl-AMP deaminase. This enzyme plays a crucial role in purine metabolism, particularly in the degradation pathway of N6-methyl-AMP, which is a minor nucleoside derivative found in tRNA and other cellular components. The N6-methyl-IMP produced by this reaction can be further metabolized into other purine derivatives or recycled back into the nucleotide pool. The N6-methyl-AMP deaminase activity is essential for maintaining proper purine homeostasis and ensuring the efficient utilization of purines in cellular processes. Its deficiency can lead to an accumulation of N6-methyl-AMP, potentially disrupting cellular metabolism and function.'
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Proteins (1)

ProteinDefinitionTaxonomy
Adenosine deaminase-like proteinAn adenosine deaminase-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6DHV7]Homo sapiens (human)

Compounds (2)

CompoundDefinitionClassesRoles
adenosine monophosphateAdenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate
adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
o(6)-methyldeoxyguanylic acidO(6)-methyldeoxyguanylic acid: incorporated into DNA by DNA polymerase I & II