Target type: molecularfunction
Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate. [PMID:29884623, RHEA:16001]
N6-methyl-AMP deaminase activity is an enzymatic activity that catalyzes the deamination of N6-methyladenosine 5'-monophosphate (N6-methyl-AMP) to N6-methylinosine 5'-monophosphate (N6-methyl-IMP). This reaction involves the removal of an amino group from the N6 position of adenine in the N6-methyl-AMP molecule, resulting in the formation of a double bond between the N6 and C6 positions of the purine ring. The enzyme responsible for this activity is known as N6-methyl-AMP deaminase. This enzyme plays a crucial role in purine metabolism, particularly in the degradation pathway of N6-methyl-AMP, which is a minor nucleoside derivative found in tRNA and other cellular components. The N6-methyl-IMP produced by this reaction can be further metabolized into other purine derivatives or recycled back into the nucleotide pool. The N6-methyl-AMP deaminase activity is essential for maintaining proper purine homeostasis and ensuring the efficient utilization of purines in cellular processes. Its deficiency can lead to an accumulation of N6-methyl-AMP, potentially disrupting cellular metabolism and function.'
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Protein | Definition | Taxonomy |
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Adenosine deaminase-like protein | An adenosine deaminase-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6DHV7] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
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adenosine monophosphate | Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical |
o(6)-methyldeoxyguanylic acid | O(6)-methyldeoxyguanylic acid: incorporated into DNA by DNA polymerase I & II |