Target type: molecularfunction
Catalysis of the reaction: choline phosphate + H2O = choline + phosphate. [EC:3.1.3.75]
Phosphocholine phosphatase activity refers to the enzymatic removal of a phosphate group from phosphocholine, a molecule with a crucial role in various cellular processes. This hydrolysis reaction breaks the bond between the phosphate group and the choline molecule, generating choline and inorganic phosphate. Phosphocholine phosphatases are categorized as phosphohydrolases, specifically belonging to the EC 3.1.3.8 group. They play a significant role in the metabolism of phospholipids, particularly in the breakdown of phosphatidylcholine, a major component of cell membranes. This hydrolysis reaction generates diacylglycerol, a signaling molecule involved in various cellular processes, and choline, which can be recycled back into the synthesis of new phospholipids. Beyond their role in lipid metabolism, phosphocholine phosphatases also contribute to the regulation of cell signaling pathways, including the activation of protein kinase C, a crucial enzyme in cell growth and differentiation. They are also involved in the modulation of membrane fluidity and the regulation of intracellular calcium levels. These diverse functions highlight the importance of phosphocholine phosphatases in maintaining cellular homeostasis and contributing to various physiological processes.'
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Protein | Definition | Taxonomy |
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Phosphoethanolamine/phosphocholine phosphatase | A phosphoethanolamine/phosphocholine phosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCT1] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
2-phenyl-1,2-benzisothiazol-3-(2h)-one | 2-phenyl-1,2-benzisothiazol-3-(2H)-one: structure given in first source; sulfur analog of ebselen | ||
6-fluoro-2-phenyl-1,2-benzothiazol-3-one | benzothiazoles | ||
2-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-1,2-benzothiazol-3-one | sulfonamide | ||
2-[[3-(3-oxo-1,2-benzothiazol-2-yl)phenyl]sulfonylamino]benzoic acid | sulfonamide | ||
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamide | sulfonamide | ||
2-(3-chlorophenyl)-1,2-benzothiazol-3-one | benzothiazoles | ||
2-(4-fluorophenyl)-1,2-benzothiazol-3-one | benzothiazoles |