Page last updated: 2024-10-24

phosphothreonine residue binding

Definition

Target type: molecularfunction

Binding to a phosphorylated threonine residue within a protein. [GOC:ai]

Phosphothreonine residue binding is a molecular function that involves the specific recognition and interaction of a protein or other molecule with a phosphorylated threonine residue. This type of binding plays a critical role in signal transduction pathways, protein-protein interactions, and the regulation of various cellular processes.

Phosphorylation of threonine residues is a reversible modification that can alter the conformation and activity of proteins. When a threonine residue is phosphorylated, it acquires a negative charge, which can create new binding sites for other molecules. These interactions can lead to changes in protein activity, localization, or stability.

Proteins that bind to phosphothreonine residues typically contain specific domains or motifs that recognize and interact with the phosphorylated threonine. These domains often include positively charged residues or hydrophobic pockets that can interact with the negatively charged phosphate group and the surrounding amino acids.

The binding of a protein to a phosphothreonine residue can have a variety of downstream effects. For example, it can:

* **Activate or inhibit the activity of the target protein**
* **Recruit other proteins to the complex**
* **Promote or prevent the degradation of the target protein**
* **Change the localization of the target protein**

In summary, phosphothreonine residue binding is a crucial molecular function that enables proteins to specifically interact with and regulate the activity of other molecules. This interaction plays a fundamental role in a wide range of cellular processes, from signal transduction to protein trafficking and gene expression.'
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Proteins (1)

ProteinDefinitionTaxonomy
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1A peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13526]Homo sapiens (human)

Compounds (8)

CompoundDefinitionClassesRoles
juglonejuglone : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogen at position 5 has been replaced by a hydroxy group. A plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.

juglone: structure
hydroxy-1,4-naphthoquinonegeroprotector;
herbicide;
reactive oxygen species generator
cycloheximidecycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.

Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol
anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
1,4-naphthoquinone1,4-naphthoquinone : The parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties.

naphthoquinone : A polycyclic aromatic ketone metabolite of naphthalene.
1,4-naphthoquinones
glycyrrhetinic acidcyclic terpene ketone;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid
immunomodulator;
plant metabolite
epigallocatechin gallate(-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.

epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis)
flavans;
gallate ester;
polyphenol
antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
propazolepropazole: RN given refers to parent cpd; structurebenzimidazoles
tretinoinall-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.

retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).

Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
retinoic acid;
vitamin A
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
acetyl-11-ketoboswellic acidacetyl-11-ketoboswellic acid: a 5-lipoxygenase inhibitor; structure given in first sourcetriterpenoid