Target type: molecularfunction
Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose-2-phosphate + nicotinamide. [RHEA:19849]
NADP+ nucleosidase activity is a crucial enzyme activity involved in the hydrolysis of nicotinamide adenine dinucleotide phosphate (NADP+). This hydrolysis results in the cleavage of the glycosidic bond between the nicotinamide moiety and the adenosine diphosphate ribose moiety of NADP+. Specifically, the enzyme catalyzes the following reaction:
NADP+ + H2O --u003e nicotinamide + adenosine diphosphate 2'-phosphate
This reaction is crucial in various metabolic pathways, particularly in the salvage pathway for nicotinamide. This pathway is essential for the biosynthesis of NAD+ and NADP+, which are fundamental coenzymes in numerous redox reactions within the cell.
NADP+ nucleosidase activity plays a vital role in the regulation of NADP+ levels and the production of nicotinamide, which can be recycled into NAD+ or NADP+. This enzyme activity is also involved in the degradation of NADP+ and the production of nicotinamide, a precursor for the synthesis of other important molecules like tryptophan and nicotinic acid.
The activity of NADP+ nucleosidase is highly regulated and influenced by various factors, including substrate concentration, pH, and the presence of inhibitors. Understanding the molecular function of NADP+ nucleosidase activity provides valuable insights into the intricate mechanisms governing NADP+ metabolism and its crucial role in maintaining cellular redox balance and overall cellular function.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| NAD(+) hydrolase SARM1 | An NAD(+) hydrolase SARM1 that is encoded in the genome of human. [PRO:CNA] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| niacinamide | nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. | pyridine alkaloid; pyridinecarboxamide; vitamin B3 | anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor |
| rabeprazole | Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. | benzimidazoles; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor |
| phenazopyridine hydrochloride | phenazopyridine hydrochloride : A hydrochloride obtained by combining phenazopyridine with one equivalent of hydrochloric acid. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. | hydrochloride | carcinogenic agent; local anaesthetic; non-narcotic analgesic |
| Berberine chloride (TN) | organic molecular entity | ||
| tenatoprazole | Tenatoprazole: structure in first source | imidazopyridine | |
| nitrofurazone | nitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections. Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS. | ||
| dexlansoprazole | Dexlansoprazole: The R-isomer of lansoprazole that is used to treat severe GASTROESOPHAGEAL REFLUX DISEASE. | benzimidazoles; sulfoxide |