Page last updated: 2024-10-24

NADP+ nucleosidase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose-2-phosphate + nicotinamide. [RHEA:19849]

NADP+ nucleosidase activity is a crucial enzyme activity involved in the hydrolysis of nicotinamide adenine dinucleotide phosphate (NADP+). This hydrolysis results in the cleavage of the glycosidic bond between the nicotinamide moiety and the adenosine diphosphate ribose moiety of NADP+. Specifically, the enzyme catalyzes the following reaction:

NADP+ + H2O --u003e nicotinamide + adenosine diphosphate 2'-phosphate

This reaction is crucial in various metabolic pathways, particularly in the salvage pathway for nicotinamide. This pathway is essential for the biosynthesis of NAD+ and NADP+, which are fundamental coenzymes in numerous redox reactions within the cell.

NADP+ nucleosidase activity plays a vital role in the regulation of NADP+ levels and the production of nicotinamide, which can be recycled into NAD+ or NADP+. This enzyme activity is also involved in the degradation of NADP+ and the production of nicotinamide, a precursor for the synthesis of other important molecules like tryptophan and nicotinic acid.

The activity of NADP+ nucleosidase is highly regulated and influenced by various factors, including substrate concentration, pH, and the presence of inhibitors. Understanding the molecular function of NADP+ nucleosidase activity provides valuable insights into the intricate mechanisms governing NADP+ metabolism and its crucial role in maintaining cellular redox balance and overall cellular function.'
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Proteins (1)

ProteinDefinitionTaxonomy
NAD(+) hydrolase SARM1An NAD(+) hydrolase SARM1 that is encoded in the genome of human. [PRO:CNA]Homo sapiens (human)

Compounds (7)

CompoundDefinitionClassesRoles
niacinamidenicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.pyridine alkaloid;
pyridinecarboxamide;
vitamin B3
anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
rabeprazoleRabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.benzimidazoles;
pyridines;
sulfoxide
anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
phenazopyridine hydrochloridephenazopyridine hydrochloride : A hydrochloride obtained by combining phenazopyridine with one equivalent of hydrochloric acid. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.hydrochloridecarcinogenic agent;
local anaesthetic;
non-narcotic analgesic
Berberine chloride (TN)organic molecular entity
tenatoprazoleTenatoprazole: structure in first sourceimidazopyridine
nitrofurazonenitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections.

Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.
dexlansoprazoleDexlansoprazole: The R-isomer of lansoprazole that is used to treat severe GASTROESOPHAGEAL REFLUX DISEASE.benzimidazoles;
sulfoxide