Target type: molecularfunction
Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate. [EC:2.8.2.25, RHEA:13453]
Flavonol 3-sulfotransferase activity is a type of enzyme activity that catalyzes the transfer of a sulfate group from a donor molecule, typically 3'-phosphoadenosine 5'-phosphosulfate (PAPS), to the 3-hydroxyl group of flavonol molecules. Flavonols are a class of flavonoids, which are plant secondary metabolites with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. The sulfation of flavonols by flavonol 3-sulfotransferases can significantly alter their properties, including their solubility, stability, and biological activity. This modification can impact their interactions with other molecules, their transport within the plant, and their ability to exert their biological effects. Flavonol 3-sulfotransferase activity is involved in a variety of plant processes, including the regulation of flavonoid biosynthesis, the defense against pathogens and herbivores, and the response to environmental stresses. The specific role of this activity varies depending on the plant species and the context. In some cases, flavonol sulfation can lead to the detoxification of flavonoids, while in other cases it can enhance their activity.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sulfotransferase 1A1 | A sulfotransferase 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50225] | Homo sapiens (human) |
| Sulfotransferase 1E1 | A sulfotransferase 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49888] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| amoxapine | amoxapine : A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position. Amoxapine: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression. | dibenzooxazepine | adrenergic uptake inhibitor; antidepressant; dopaminergic antagonist; geroprotector; serotonin uptake inhibitor |
| protriptyline | Protriptyline: Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation. | carbotricyclic compound | antidepressant |
| ethinyl estradiol | 17alpha-ethynylestradiol : A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. | 17-hydroxy steroid; 3-hydroxy steroid; terminal acetylenic compound | xenoestrogen |
| 2-naphthol | 2-naphthol : A naphthol carrying a hydroxy group at position 2. 2-naphthol: RN given refers to parent cpd naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent. | naphthol | antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger |
| 5-hydroxyindole | hydroxyindoles | human metabolite | |
| 6-hydroxybenzothiazole | |||
| 6-hydroxyindole | 6-hydroxyindole: structure in first source | ||
| 4-hydroxytoremifene | 4-hydroxytoremifene: metabolite of toremifene; RN refers to (Z)-isomer; structure in first source | ||
| 5-hydroxybenzimidazole | 5-hydroxybenzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole carrying a single hydroxy substituent at position 5. 5-hydroxybenzimidazole: only base detected in cobamide cpds from methanol-grown Methanosarcina barkeri | benzimidazoles; phenols | bacterial metabolite; human metabolite; rat metabolite |
| 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole |