7-dehydrocholesterol reductase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH. [RHEA:23984]

7-dehydrocholesterol reductase activity, also known as DHCR7 activity, is a crucial enzymatic step in the biosynthesis of cholesterol. This enzyme catalyzes the reduction of 7-dehydrocholesterol (7-DHC), a precursor to cholesterol, to cholesterol. The reaction involves the transfer of a hydride ion from NADPH to the double bond at carbon 7 of 7-DHC. This specific enzymatic activity is essential for the production of cholesterol, a vital molecule involved in various cellular processes, including membrane fluidity, hormone synthesis, and vitamin D production. Deficiency in DHCR7 activity leads to Smith-Lemli-Opitz syndrome (SLOS), a rare genetic disorder characterized by severe neurological impairments, developmental delays, and physical abnormalities.'
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Proteins (2)

Compounds (2)