collagen receptor activity

Definition

Target type: molecularfunction

Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:uh, PMID:21568710]

Collagen receptors are transmembrane proteins that bind to collagen, a fibrous protein found in connective tissues. They play a crucial role in a wide range of biological processes, including cell adhesion, migration, proliferation, and differentiation. Collagen receptor activity is a molecular function that describes the ability of a protein to interact with collagen molecules. This interaction is mediated by specific binding domains within the receptor protein, which recognize and bind to specific epitopes on the collagen molecule.

The binding of collagen to its receptor triggers a cascade of intracellular signaling events, leading to the activation of downstream signaling pathways. These pathways regulate various cellular functions, such as cytoskeletal reorganization, gene expression, and cell survival.

Collagen receptors can be divided into different families based on their structural features and signaling mechanisms. Some of the major families include:

* **Integrins:** Integrins are heterodimeric transmembrane receptors that bind to a wide variety of extracellular matrix proteins, including collagen. They are involved in cell adhesion, migration, and signal transduction.
* **Discoidin domain receptors (DDRs):** DDRs are single-pass transmembrane receptors that specifically bind to collagen. They are tyrosine kinases that activate downstream signaling pathways involved in cell growth, differentiation, and angiogenesis.
* **Leukocyte-associated immunoglobulin-like receptor (LAIR)-1:** LAIR-1 is a transmembrane receptor that binds to collagen and inhibits immune cell activation. It is involved in the regulation of inflammatory responses.
* **Collagen triple helix repeat containing (CTHRC) proteins:** CTHRC proteins are secreted proteins that bind to collagen and modulate its assembly and function.

Mutations in collagen receptors can lead to a variety of diseases, including connective tissue disorders, immune deficiencies, and cancer. Therefore, understanding the molecular function of collagen receptor activity is crucial for developing new therapeutic strategies for these diseases.'
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Proteins (2)

Compounds (12)