CDP phosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: CDP + H2O = CMP + phosphate. [GOC:al, RHEA:64880]

CDP phosphatase activity refers to the enzymatic hydrolysis of cytidine 5'-diphospho- (CDP-) linked molecules, specifically the cleavage of the phosphate monoester bond between the 5'-hydroxyl group of the ribose moiety and the phosphate group. This process releases inorganic phosphate (Pi) and generates the corresponding cytidine monophosphate (CMP) derivative. CDP phosphatases play a crucial role in various cellular processes, including:

1. **Nucleotide metabolism:** CDP phosphatases participate in the interconversion of different nucleotide forms, ensuring a balanced supply of essential building blocks for DNA, RNA, and other cellular components.

2. **Lipid biosynthesis:** CDP phosphatases are involved in the synthesis of phospholipids, essential components of cell membranes, by hydrolyzing CDP-diacylglycerol (CDP-DAG) to yield phosphatidic acid (PA), a precursor for various phospholipids.

3. **Signal transduction:** Certain CDP phosphatases act as signaling molecules, regulating intracellular pathways by hydrolyzing specific CDP-linked compounds and generating second messengers.

4. **Other cellular processes:** CDP phosphatases are involved in various other cellular processes, including cell growth, differentiation, and immune response.

The specificity of CDP phosphatases can vary, with some enzymes acting on a broad range of CDP-linked molecules, while others exhibit substrate specificity for specific CDP-derivatives. The regulation of CDP phosphatase activity is essential for maintaining cellular homeostasis and preventing aberrant signaling. Mutations or dysregulation of CDP phosphatases can lead to various diseases, including neurological disorders and metabolic syndromes.'
"

Proteins (3)

Compounds (3)