Target type: molecularfunction
Binding to a triester of glycerol. [GOC:jl, ISBN:0198506732]
Triglyceride binding is a molecular function that involves the interaction of a protein or other molecule with a triglyceride molecule. Triglycerides are the main form of fat stored in the body and are composed of three fatty acids linked to a glycerol molecule. Triglyceride binding proteins play a crucial role in various biological processes, including:
1. **Lipid Metabolism:** Triglyceride binding proteins facilitate the transport, storage, and utilization of triglycerides. They bind to triglycerides in the bloodstream and deliver them to tissues where they are needed for energy production or stored for later use.
2. **Lipoprotein Assembly and Secretion:** Triglycerides are packaged into lipoproteins, such as very-low-density lipoproteins (VLDL), for transport in the blood. Triglyceride binding proteins participate in the assembly and secretion of these lipoproteins.
3. **Fat Digestion:** Triglyceride binding proteins in the digestive system aid in the breakdown of dietary fats. They bind to triglycerides in the gut and facilitate their absorption into the bloodstream.
4. **Signal Transduction:** Some triglyceride binding proteins act as receptors that bind to specific ligands, triggering downstream signaling pathways. This allows cells to respond to changes in lipid levels and regulate metabolic processes.
5. **Cellular Function:** Triglyceride binding proteins are involved in various cellular functions, including cell growth, differentiation, and apoptosis. They can regulate lipid storage and release, affecting cellular energy balance.
The mechanism of triglyceride binding can vary depending on the protein involved. Some proteins bind to the glycerol backbone of the triglyceride, while others interact with the fatty acid chains. The binding affinity and specificity of these proteins can also differ, contributing to their diverse roles in lipid metabolism and cellular function.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Cholesteryl ester transfer protein | A cholesteryl ester transfer protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11597] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| niacin | Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms). | pyridine alkaloid; pyridinemonocarboxylic acid; vitamin B3 | antidote; antilipemic drug; EC 3.5.1.19 (nicotinamidase) inhibitor; Escherichia coli metabolite; human urinary metabolite; metabolite; mouse metabolite; plant metabolite; vasodilator agent |
| ursolic acid | hydroxy monocarboxylic acid; pentacyclic triterpenoid | geroprotector; plant metabolite | |
| torcetrapib | (trifluoromethyl)benzenes; carbamate ester; quinolines | anticholesteremic drug; CETP inhibitor | |
| sb 203580 | imidazoles; monofluorobenzenes; pyridines; sulfoxide | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent | |
| delta-8-tetrahydrocannabinol | 1-benzopyran | ||
| 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin | 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: structure in first source alvespimycin : A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. | 1,4-benzoquinones; ansamycin; carbamate ester; secondary amino compound; tertiary amino compound | Hsp90 inhibitor |
| tanespimycin | CP 127374: analog of herbimycin A | 1,4-benzoquinones; ansamycin; carbamate ester; organic heterobicyclic compound; secondary amino compound | antineoplastic agent; apoptosis inducer; Hsp90 inhibitor |
| dalcetrapib | dalcetrapib: inhibits cholesteryl ester transfer protein (CETP) | anilide | |
| am-411 | |||
| sc 795 | |||
| 3-((3-(4-chloro-3-ethylphenoxy)phenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)-1,1,1-trifluoropropan-2-ol | 3-((3-(4-chloro-3-ethylphenoxy)phenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)-1,1,1-trifluoropropan-2-ol: inhibits cholesteryl ester transfer protein; structure in first source | ||
| amg 3 | AMG 3: structure in first source | ||
| km-233 | KM-233: used for the treatment of high-grade glioma; structure in first source | ||
| mk 0354 | |||
| anacetrapib | |||
| gdc 0941 | pictrelisib : A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring. | indazoles; morpholines; piperazines; sulfonamide; thienopyrimidine | EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor |
| skepinone-l | skepinone-L: a dibenzosuberone-type p38 MAPK inhibitor; structure in first source | ||
| evacetrapib | benzazepine |