hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Definition

Target type: molecularfunction

Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. [GOC:jl]

Hydrolases are enzymes that catalyze the cleavage of chemical bonds by the addition of a water molecule. Specifically, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, involves the hydrolysis of non-peptide C-N bonds. This broad category encompasses enzymes that break down a wide variety of molecules, including amides, amidines, and other nitrogen-containing compounds. These enzymes play crucial roles in diverse biological processes, such as:

- **Metabolism:** Hydrolyzing nitrogen-containing compounds to break down complex molecules into simpler ones that can be further utilized in metabolic pathways.
- **Detoxification:** Degrading harmful nitrogenous compounds, such as drugs and toxins, into less toxic byproducts.
- **Cellular signaling:** Acting on signaling molecules containing non-peptide C-N bonds to regulate cellular processes.
- **Biopolymer degradation:** Breaking down biopolymers, like chitin and glycoproteins, that contain non-peptide C-N bonds.

Examples of enzymes with this hydrolase activity include:

- **Amidases:** Catalyze the hydrolysis of amides, releasing an amine and a carboxylic acid.
- **Amidinases:** Catalyze the hydrolysis of amidines, releasing an amine and a carboxylic acid.
- **Deaminases:** Catalyze the removal of an amine group from a molecule, releasing ammonia.
- **Glycosidases:** Catalyze the hydrolysis of glycosidic bonds, which involve C-N bonds in some cases.

The diversity of substrates and their involvement in various biological processes highlight the significant role of hydrolases, acting on carbon-nitrogen (but not peptide) bonds, in maintaining cellular function and homeostasis.'
"

Proteins (1)

Compounds (11)