Page last updated: 2024-10-24

serine O-acyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule. [GOC:ai]

Serine O-acyltransferases are a class of enzymes that catalyze the transfer of an acyl group from an acyl donor, such as acetyl-CoA or propionyl-CoA, to the hydroxyl group of serine residues in a protein substrate. This process, known as O-acylation, is a common post-translational modification that can alter the structure, function, and stability of proteins. O-acylation is often involved in regulating protein-protein interactions, cellular signaling pathways, and enzyme activity. The mechanism of serine O-acyltransferase activity typically involves the formation of a covalent intermediate between the enzyme and the acyl donor. The acyl group is then transferred to the hydroxyl group of serine in the substrate protein, resulting in the formation of an ester bond. Serine O-acyltransferases exhibit a wide range of substrate specificity, with some enzymes targeting specific protein substrates while others have broader activity. The activity of these enzymes is often regulated by factors such as phosphorylation, allosteric regulation, and protein-protein interactions. Serine O-acyltransferases play diverse roles in cellular processes, including lipid metabolism, protein trafficking, signal transduction, and gene regulation. Dysregulation of serine O-acyltransferase activity has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders.'
"

Proteins (1)

ProteinDefinitionTaxonomy
Ghrelin O-acyltransferaseA ghrelin O-acyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96T53]Homo sapiens (human)

Compounds (11)

CompoundDefinitionClassesRoles
ethylmaleimideEthylmaleimide: A sulfhydryl reagent that is widely used in experimental biochemical studies.maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
estroneHydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.17-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols
antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
2-cyclohexen-1-one2-cyclohexen-1-one: RN given refers to unlabeled cpd with specified locant for double bond

cyclohex-2-enone : A cyclohexenone having its C=C double bond at the 2-position.

cyclohexenone : The parent compound of the cyclohexenones, composed of cyclohexanone having one double bond in the ring.
cyclohexenone
ursolic acidhydroxy monocarboxylic acid;
pentacyclic triterpenoid
geroprotector;
plant metabolite
cholest-4-en-3-onecholest-4-en-3-one : A cholestanoid that is cholest-4-ene substituted by an oxo group at position 3.3-oxo-Delta(4) steroid;
cholestanoid
human metabolite;
plant metabolite
taraxeroltaraxerol : A pentacyclic triterpenoid that is oleanan-3-ol lacking the methyl group at position 14, with an alpha-methyl substituent at position 13 and a double bond between positions 14 and 15.

taraxerol: structure
pentacyclic triterpenoid;
secondary alcohol
metabolite
androstan-3-one
Bardoxolonecyclohexenones
bardoxolone methylmethyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate: structure in first sourcecyclohexenones
1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole
2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide: synthetic potential anticarcinogenic