Target type: molecularfunction
Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA. [EC:2.3.1.42, RHEA:17657]
Glycerone-phosphate O-acyltransferase activity catalyzes the transfer of an acyl group from an acyl donor, such as acyl-CoA, to the hydroxyl group at the sn-1 position of glycerone phosphate. This reaction is the first committed step in the biosynthesis of triacylglycerols (TAGs) and phospholipids, which are essential components of cell membranes and energy storage. Glycerone phosphate O-acyltransferases are highly specific for their substrates, and different enzymes have different preferences for acyl donors and acceptors. For example, some enzymes prefer long-chain fatty acids, while others prefer short-chain fatty acids. The activity of glycerone phosphate O-acyltransferases is regulated by various factors, including substrate availability, enzyme phosphorylation, and the presence of specific inhibitors. This regulation ensures that the synthesis of TAGs and phospholipids is tightly controlled in response to cellular needs.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Dihydroxyacetone phosphate acyltransferase | A dihydroxyacetone phosphate acyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15228] | Homo sapiens (human) |
| Dihydroxyacetone phosphate acyltransferase | A dihydroxyacetone phosphate acyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15228] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| chloramphenicol | Amphenicol: Chloramphenicol and its derivatives. | C-nitro compound; carboxamide; diol; organochlorine compound | antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor |
| carbenicillin | carbenicillin : A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain. Carbenicillin: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function. | penicillin; penicillin allergen | antibacterial drug |
| tetracycline | tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. |