Target type: molecularfunction
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in). [TC:2.A.26.1.1]
Branched-chain amino acid:sodium symporter activity is a transmembrane transport process that facilitates the simultaneous movement of branched-chain amino acids (BCAAs) and sodium ions across a cell membrane. BCAAs, including leucine, isoleucine, and valine, are essential amino acids that play crucial roles in protein synthesis, muscle growth, and energy metabolism. Sodium ions, on the other hand, are involved in various cellular processes, including maintaining osmotic balance and generating electrochemical gradients. This symporter activity is driven by the electrochemical gradient of sodium ions, which provides the energy for the uphill transport of BCAAs against their concentration gradient. The process involves the binding of both BCAAs and sodium ions to specific sites on the symporter protein, leading to a conformational change that allows their translocation across the membrane. This coordinated transport ensures the efficient uptake of BCAAs into cells, where they are utilized for various metabolic pathways. Notably, the activity of this symporter is tightly regulated by factors such as substrate availability, hormonal signals, and cellular energy status, ensuring optimal BCAA uptake and utilization. The symporter activity is essential for maintaining BCAA homeostasis, supporting muscle protein synthesis, and contributing to overall metabolic health.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sodium-dependent neutral amino acid transporter B(0)AT2 | A sodium-dependent neutral amino acid transporter B(0)AT2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2J7] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| loratadine | loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders. Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness. | benzocycloheptapyridine; ethyl ester; N-acylpiperidine; organochlorine compound; tertiary carboxamide | anti-allergic agent; cholinergic antagonist; geroprotector; H1-receptor antagonist |
| sch 37370 | N-acetyldesloratadine: dual antagonist of platelet-activating factor and histamine | ||
| desloratadine | desloratadine : Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness. desloratadine: major metabolite of loratadine | benzocycloheptapyridine | anti-allergic agent; cholinergic antagonist; drug metabolite; H1-receptor antagonist |
| rupatadine | rupatadine: structure given in first source; RN given refers to trihydrochloride | benzocycloheptapyridine |