Target type: molecularfunction
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in). [TC:2.A.41.2.1]
Purine-specific nucleoside:sodium symporter activity describes the protein's ability to transport purine nucleosides across cell membranes. This transport is coupled to the movement of sodium ions down their electrochemical gradient. The transporter protein binds both the purine nucleoside and sodium ions simultaneously, facilitating their co-transport. This mechanism allows for the efficient uptake of purine nucleosides into cells, which are essential building blocks for DNA and RNA synthesis. The transporter exhibits high specificity for purine nucleosides, preferentially binding adenine, guanine, and hypoxanthine nucleosides, while exhibiting lower affinity for pyrimidine nucleosides. The sodium gradient provides the driving force for the transport process, enabling the accumulation of purine nucleosides within the cell against their concentration gradient. This activity is crucial for various physiological processes, including nucleotide biosynthesis, purine salvage pathway, and cellular signaling pathways. Disruptions in purine nucleoside:sodium symporter activity can lead to various diseases and disorders, highlighting its importance in maintaining cellular homeostasis.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Solute carrier family 28 member 3 | A solute carrier family 28 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HAS3] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| phloretin | dihydrochalcones | antineoplastic agent; plant metabolite | |
| uridine | uridines | drug metabolite; fundamental metabolite; human metabolite | |
| phlorhizin | aryl beta-D-glucoside; dihydrochalcones; monosaccharide derivative | antioxidant; plant metabolite | |
| resacetophenone | 2',4'-dihydroxyacetophenone : A dihydroxyacetophenone that is acetophenone carrying hydroxy substituents at positions 2' and 4'. resacetophenone: structure in first source | dihydroxyacetophenone; resorcinols | plant metabolite |
| adenosine | quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | adenosines; purines D-ribonucleoside | analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent |
| 4-nitrobenzylthioinosine | 4-nitrobenzylthioinosine: inhibitor of nucleoside transport; acts on ENT1 | purine nucleoside | |
| 2,4,6-trihydroxyacetophenone | 2',4',6'-trihydroxyacetophenone : A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acidic glycans and glycopeptides. monoacetylphloroglucinol: structure in first source | aromatic ketone; benzenetriol; methyl ketone | MALDI matrix material; plant metabolite |
| 2,6-dihydroxyacetophenone | 2,6-dihydroxyacetophenone: inhibits aminopyrine-N-demethylase in rat liver microsomal preparations | aromatic ketone | |
| tecadenoson | tecadenoson: an A1 adenosine receptor agonist | ||
| trilobatin | trilobatin : An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage. It is isolated from the leaves of the Chinese sweet tea Lithocarpus polystachyus and exhibits significant anti-hyperglycemic, anti-oxidative and anti-inflammatory properties. trilobatin: anti-inflammatory from Lithocarpus polystachyus leaves; structure in first source | aryl beta-D-glucoside; dihydrochalcones; monosaccharide derivative | anti-inflammatory agent; antioxidant; plant metabolite; sweetening agent |