Target type: molecularfunction
Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, RHEA:35031]
L-serine transmembrane transporter activity refers to the process by which a protein facilitates the movement of the amino acid L-serine across a cell membrane. This process is crucial for maintaining cellular homeostasis, as L-serine is a critical component of proteins and is involved in various metabolic pathways. L-serine transporters are integral membrane proteins that typically use a concentration gradient or electrochemical potential to drive the movement of L-serine. The transport mechanism can be active, meaning it requires energy, or passive, relying solely on the difference in concentration between the inside and outside of the cell. These transporters often exhibit selectivity for L-serine, meaning they preferentially bind and transport this specific amino acid over others. The activity of L-serine transporters is regulated by a variety of factors, including substrate concentration, pH, and the presence of specific inhibitors. Disruptions in L-serine transporter activity can lead to various cellular dysfunctions, highlighting their importance in maintaining proper cellular function.'
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Protein | Definition | Taxonomy |
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Neutral amino acid transporter B(0) | A neutral amino acid transporter B(0) that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15758] | Homo sapiens (human) |
Neutral amino acid transporter A | A neutral amino acid transporter A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43007] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
hydroxyproline | hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group. Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation. | 4-hydroxyproline; L-alpha-amino acid zwitterion | human metabolite; mouse metabolite; plant metabolite |
serine | serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids. | L-alpha-amino acid; proteinogenic amino acid; serine; serine family amino acid; serine zwitterion | algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
glutamine | glutamine : An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4. Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. L-glutamine : An optically active form of glutamine having L-configuration. | amino acid zwitterion; glutamine; glutamine family amino acid; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite |
asparagine | asparagine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group. Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) | amino acid zwitterion; asparagine; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite |
4-hydroxyphenylglycine, (s)-isomer | L-4-hydroxyphenylglycine : The L-enantiomer of 4-hydroxyphenylglycine. | 4-hydroxyphenylglycine | |
D-serine | D-alpha-amino acid; serine; serine zwitterion | Escherichia coli metabolite; human metabolite; NMDA receptor agonist | |
gamma-glutamine-4-nitroanilide | gamma-glutamine-4-nitroanilide: substrate for glutaminase B.; RN given refers to (L)-isomer | ||
proline | proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2. Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons. | amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid | algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite |