Target type: molecularfunction
Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. [EC:1.1.1.169, RHEA:16233]
2-dehydropantoate 2-reductase activity is a crucial step in the biosynthesis of pantothenate (vitamin B5), a vital precursor for coenzyme A (CoA). CoA plays a fundamental role in various metabolic pathways, including carbohydrate, lipid, and amino acid metabolism. This enzymatic activity catalyzes the NADPH-dependent reduction of 2-dehydropantoate to pantoate, a key intermediate in the pantothenate biosynthesis pathway. The enzyme responsible for this reaction, known as pantoate reductase, utilizes NADPH as a reducing agent to transfer electrons to the carbonyl group of 2-dehydropantoate, converting it into the corresponding alcohol, pantoate. This reduction reaction is highly specific for 2-dehydropantoate and is essential for the production of pantothenate, which is subsequently incorporated into CoA. The efficient and regulated activity of 2-dehydropantoate 2-reductase is crucial for maintaining cellular metabolism and ensuring the availability of CoA, a critical cofactor for numerous metabolic processes.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| 2-dehydropantoate 2-reductase | A 2-dehydropantoate 2-reductase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A9J4] | Escherichia coli K-12 |
| Ketol-acid reductoisomerase (NADP(+)) | A ketol-acid reductoisomerase (NADP(+)) that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P05793] | Escherichia coli K-12 |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| phosphoric acid | phosphoric acid : A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom. phosphoric acid: concise etchant is 37% H3PO4 | phosphoric acids | algal metabolite; fertilizer; human metabolite; NMR chemical shift reference compound; solvent |
| nadp | NADP | fundamental metabolite | |
| nad | NAD | geroprotector | |
| adenosine diphosphate | Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | fundamental metabolite; human metabolite |
| adenosine monophosphate | Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical |
| 1,1-cyclopropanedicarboxylate | cyclopropane-1,1-dicarboxylic acid: inhibits 1-aminocyclopropane-1-carboxylic acid oxidase; structure in first source | ||
| adenosine 2',5'-diphosphate | |||
| guanosine diphosphate | Guanosine Diphosphate: A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. | guanosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor |
| guanosine triphosphate | Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety. | guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate | Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor |