Target type: molecularfunction
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). [TC:2.A.22.2.1]
Proline-sodium symporter activity refers to the process by which a protein embedded within a cell membrane facilitates the simultaneous transport of both proline and sodium ions across the membrane. This transport is coupled, meaning that the movement of one molecule is dependent on the movement of the other. Specifically, the symporter utilizes the electrochemical gradient of sodium ions (a higher concentration of sodium outside the cell) to drive the uptake of proline into the cell. This process is energetically favorable because the inward movement of sodium ions down their concentration gradient provides the energy needed to move proline against its concentration gradient. The symporter protein binds both proline and sodium ions, and their simultaneous binding triggers a conformational change in the protein, allowing them to be transported across the membrane. This process is crucial for the absorption of proline from the gut and its subsequent utilization in various cellular processes, including protein synthesis and collagen formation.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sodium-dependent neutral amino acid transporter B(0)AT2 | A sodium-dependent neutral amino acid transporter B(0)AT2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2J7] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| loratadine | loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders. Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness. | benzocycloheptapyridine; ethyl ester; N-acylpiperidine; organochlorine compound; tertiary carboxamide | anti-allergic agent; cholinergic antagonist; geroprotector; H1-receptor antagonist |
| sch 37370 | N-acetyldesloratadine: dual antagonist of platelet-activating factor and histamine | ||
| desloratadine | desloratadine : Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness. desloratadine: major metabolite of loratadine | benzocycloheptapyridine | anti-allergic agent; cholinergic antagonist; drug metabolite; H1-receptor antagonist |
| rupatadine | rupatadine: structure given in first source; RN given refers to trihydrochloride | benzocycloheptapyridine |