Page last updated: 2024-10-24

cysteine-type endopeptidase inhibitor activity

Definition

Target type: molecularfunction

Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. [GOC:dph, GOC:tb]

Cysteine-type endopeptidase inhibitor activity is a molecular function that describes the ability of a molecule to inhibit the activity of cysteine-type endopeptidases. These enzymes are a class of proteases that utilize a cysteine residue in their active site to catalyze the hydrolysis of peptide bonds. Cysteine-type endopeptidases are involved in a wide range of biological processes, including protein degradation, signal transduction, and inflammation. Inhibitors of these enzymes can be used to study their function and to develop drugs for the treatment of various diseases.

The mechanism of inhibition of cysteine-type endopeptidases varies depending on the inhibitor. Some inhibitors bind to the active site of the enzyme and block the access of the substrate. Other inhibitors modify the active site of the enzyme, rendering it inactive. Still others inhibit the enzyme by interacting with its regulatory domains.

Examples of cysteine-type endopeptidase inhibitors include:

- E-64: A potent inhibitor of papain, a cysteine-type endopeptidase that is found in plants.
- Pepstatin A: An inhibitor of aspartic proteases, a class of enzymes that includes pepsin and renin.
- Cysteine protease inhibitors (CPIs): A family of proteins that are found in plants, animals, and fungi. CPIs inhibit the activity of cysteine-type endopeptidases by binding to their active site.

Inhibitors of cysteine-type endopeptidases are being investigated as potential therapeutic agents for a variety of diseases, including cancer, inflammatory diseases, and infectious diseases. For example, inhibitors of cathepsins, a family of cysteine-type endopeptidases that are involved in tumor growth and metastasis, are being studied as potential anticancer drugs.'
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Proteins (4)

ProteinDefinitionTaxonomy
Beta-caseinA beta-casein that is encoded in the genome of cow. [OMA:P02666, PRO:DAN]Bos taurus (cattle)
Baculoviral IAP repeat-containing protein 7A baculoviral IAP repeat-containing protein 7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96CA5]Homo sapiens (human)
E3 ubiquitin-protein ligase XIAPA baculoviral IAP repeat-containing protein 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P98170]Homo sapiens (human)
Baculoviral IAP repeat-containing protein 5A baculoviral IAP repeat-containing protein 5 that is encoded in the genome of human. [PMID:12719470, PMID:15917996, PMID:20929775, PRO:KER]Homo sapiens (human)

Compounds (16)

CompoundDefinitionClassesRoles
embelinembelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.

embelin: from Embelia fruit (Myrsinaceae)
dihydroxy-1,4-benzoquinonesantimicrobial agent;
antineoplastic agent;
hepatitis C protease inhibitor;
plant metabolite
phenylalanineL-phenylalanine : The L-enantiomer of phenylalanine.

phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.

Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid
algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
benziodaronebenziodarone: minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74)aromatic ketone
3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone : A member of the class of pyridones that is 2-pyridone carrying cyano, phenyl and 3-bromo-6-hydroxyphenyl substituents at positions 3, 4 and 6 respectivelybromophenol;
nitrile;
pyridone
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione: a GSK3beta inhibitor

TDZD-8 : A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease.
benzenes;
thiadiazolidine
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
neuroprotective agent
kaempferol7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone
antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
kaempferol 3-o-rhamnosideafzelin : A glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage.

kaempferol 3-O-rhamnoside: from apple (Malus domestica) leaves; structure in first source
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone
anti-inflammatory agent;
antibacterial agent;
plant metabolite
abt-737aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound
anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
lbw242LBW242: proapoptotic IAP inhibitor; low MW Smac (Second mitochondria-derived activator of caspases) mimetic; structure in first source
sm 164SM 164: a bivalent Smac mimetic with antineoplastic activity; structure in first sourcebenzenes;
organic heterobicyclic compound;
secondary carboxamide;
triazoles
antineoplastic agent;
apoptosis inducer;
radiosensitizing agent
lcl1611,3-thiazoles;
aromatic ketone;
L-alanine derivative;
monofluorobenzenes;
N-acylpyrrolidine
antineoplastic agent;
apoptosis inducer
at 406
gdc-0152GDC-0152: structure in first source
birinapantbirinapant: a Smac mimetic with antineoplastic activitydipeptide
nvp-cgm097NVP-CGM097: an MDM2 and HDM2 inhibitor; structure in first source
2-carboxyarabinitol 1-phosphate