phosphoribosylaminoimidazolecarboxamide formyltransferase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. [EC:2.1.2.3]
Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate (THF) to the N-10 position of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), a key step in the de novo purine biosynthesis pathway. This reaction is essential for the production of purine nucleotides, such as adenosine triphosphate (ATP) and guanosine triphosphate (GTP), which are vital for a wide range of cellular functions, including energy production, signal transduction, and protein synthesis. The enzyme is highly specific for its substrates, and the reaction mechanism involves the formation of a ternary complex between the enzyme, AICAR, and 10-formylTHF. The enzyme utilizes a catalytic mechanism that involves the transfer of the formyl group from 10-formylTHF to a conserved glutamate residue on the enzyme, followed by the transfer of the formyl group from the glutamate residue to AICAR. This process is crucial for the efficient and precise synthesis of purine nucleotides, and disruptions in the activity of AICAR transformylase can lead to a variety of metabolic disorders.'
"
Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Bifunctional purine biosynthesis protein ATIC | A bifunctional purine biosynthesis protein ATIC that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31939] | Homo sapiens (human) |
Compounds (9)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| sulfasalazine | sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position. Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907) | ||
| veratridine | steroid | sodium channel modulator | |
| aica ribonucleotide | AICA ribonucleotide : A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative. AICA ribonucleotide: purine precursor that has antineoplastic activity | 1-(phosphoribosyl)imidazolecarboxamide; aminoimidazole | cardiovascular drug; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite |
| methotrexate | dicarboxylic acid; monocarboxylic acid amide; pteridines | abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent | |
| 5-formamidoimidazole-4-carboxamide ribotide | 5-formamidoimidazole-4-carboxamide ribotide: purine precursor | 1-(phosphoribosyl)imidazolecarboxamide | Escherichia coli metabolite; mouse metabolite |
| nsc 88915 | 4-pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate): a tyrosyl-DNA phosphodiesterase inhibitor; structure in first source | ||
| 5,11-methenyltetrahydrohomofolate | |||
| pemetrexed | pemetrexed disodium : An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). | N-acyl-L-glutamic acid; pyrrolopyrimidine | antimetabolite; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; EC 2.1.1.45 (thymidylate synthase) inhibitor; EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor |
| lometrexol | lometrexol: RN & structure given in first source; |