Compounds > 5-formamidoimidazole-4-carboxamide ribotide
Page last updated: 2024-11-08

5-formamidoimidazole-4-carboxamide ribotide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-formamidoimidazole-4-carboxamide ribotide: purine precursor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID166760
CHEMBL ID521310
CHEBI ID18381
SCHEMBL ID4360247
MeSH IDM0171856

Synonyms (27)

Synonym
unii-kny2d67ft5
1h-imidazole-4-carboxamide, 5-(formylamino)-1-(5-o-phosphono-beta-d-ribofuranosyl)-
kny2d67ft5 ,
CHEBI:18381 ,
1-(4-carbamoyl-5-formamido-1h-imidazol-1-yl)-1-deoxy-d-ribofuranose 5-(dihydrogen phosphate)
bdbm22586
1-(5 -phosphoribosyl)-5-formamido-4-imidazolecarboxamide
{[(2r,3s,4r,5r)-5-(4-carbamoyl-5-formamido-1h-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
5-formamido-1-(5-phospho-d-ribosyl)imidazole-4-carboxamide
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide
1-(5'-phosphoribosyl)-5-formamido-4-imidazolecarboxamide
faicar
5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
C04734
5-(formylamino)-1-(5-o-phosphono-beta-d-ribofuranosyl)-1h-imidazole-4-carboxamide
5-formamidoimidazole-4-carboxamide ribotide
13018-54-7
SCHEMBL4360247
CHEMBL521310
phosphoribosyl formamidocarboxamide
[(2r,3s,4r,5r)-5-(4-carbamoyl-5-formamidoimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
DTXSID50156384
5-formylamino-4-imidazolecarboxamide ribonucleotide
5-formamido-1-(5-phosphoribosyl)-imidazole-4-carboxamide
Q2817110
5-formylamino-4-imidazolecarboxamideribonucleotide
imidazole-4-carboxamide, 5-formamido-1-beta-d-ribofuranosyl-, 5'-(dihydrogen phosphate)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
1-(phosphoribosyl)imidazolecarboxamide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (31)

PathwayProteinsCompounds
Purine Metabolism3766
Adenosine Deaminase Deficiency3766
Adenylosuccinate Lyase Deficiency3766
Gout or Kelley-Seegmiller Syndrome3766
Lesch-Nyhan Syndrome (LNS)3766
Molybdenum Cofactor Deficiency3766
Xanthine Dehydrogenase Deficiency (Xanthinuria)3766
Purine Nucleoside Phosphorylase Deficiency3766
AICA-Ribosiduria3766
Azathioprine Action Pathway4782
Mercaptopurine Action Pathway4780
Thioguanine Action Pathway4781
Xanthinuria Type I3766
Xanthinuria Type II3766
Adenine Phosphoribosyltransferase Deficiency (APRT)3766
Mitochondrial DNA Depletion Syndrome-33766
Myoadenylate Deaminase Deficiency3766
Purine Nucleotides De Novo Biosynthesis2945
One Carbon Pool by Folate1227
Purine Nucleotides De Novo Biosynthesis 22945
One Carbon Pool by Folate I527
Mitochondrial DNA Depletion Syndrome3566
Folate metabolism ( Folate metabolism )2039
Purine nucleotides and Nucleosides metabolism ( Purine nucleotides and Nucleosides metabolism )10577
IMP + H2O = 5'-Phospho-ribosyl-4-carboxamido-5-formamido-imidazole ( Purine nucleotides and Nucleosides metabolism )13
The impact of Nsp14 on metabolism (COVID-19 Disease Map)084
purine nucleotides de novo biosynthesis I039
superpathway of histidine, purine, and pyrimidine biosynthesis064
purine nucleotides de novo biosynthesis II033
Biochemical pathways: part I0466
Disorders of folate metabolism and transport1827

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Bifunctional purine biosynthesis protein ATICHomo sapiens (human)Ki0.40000.40000.64000.8800AID360482
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (13)

Processvia Protein(s)Taxonomy
brainstem developmentBifunctional purine biosynthesis protein ATICHomo sapiens (human)
nucleobase-containing compound metabolic processBifunctional purine biosynthesis protein ATICHomo sapiens (human)
GMP biosynthetic processBifunctional purine biosynthesis protein ATICHomo sapiens (human)
'de novo' IMP biosynthetic processBifunctional purine biosynthesis protein ATICHomo sapiens (human)
response to inorganic substanceBifunctional purine biosynthesis protein ATICHomo sapiens (human)
cerebellum developmentBifunctional purine biosynthesis protein ATICHomo sapiens (human)
cerebral cortex developmentBifunctional purine biosynthesis protein ATICHomo sapiens (human)
animal organ regenerationBifunctional purine biosynthesis protein ATICHomo sapiens (human)
'de novo' AMP biosynthetic processBifunctional purine biosynthesis protein ATICHomo sapiens (human)
dihydrofolate metabolic processBifunctional purine biosynthesis protein ATICHomo sapiens (human)
tetrahydrofolate biosynthetic processBifunctional purine biosynthesis protein ATICHomo sapiens (human)
'de novo' XMP biosynthetic processBifunctional purine biosynthesis protein ATICHomo sapiens (human)
cellular response to interleukin-7Bifunctional purine biosynthesis protein ATICHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
IMP cyclohydrolase activityBifunctional purine biosynthesis protein ATICHomo sapiens (human)
protein homodimerization activityBifunctional purine biosynthesis protein ATICHomo sapiens (human)
cadherin bindingBifunctional purine biosynthesis protein ATICHomo sapiens (human)
phosphoribosylaminoimidazolecarboxamide formyltransferase activityBifunctional purine biosynthesis protein ATICHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
cytosolBifunctional purine biosynthesis protein ATICHomo sapiens (human)
plasma membraneBifunctional purine biosynthesis protein ATICHomo sapiens (human)
membraneBifunctional purine biosynthesis protein ATICHomo sapiens (human)
extracellular exosomeBifunctional purine biosynthesis protein ATICHomo sapiens (human)
cytosolBifunctional purine biosynthesis protein ATICHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID360482Inhibition of IMPCH activity of human wild-type ATIC2007The Journal of biological chemistry, Apr-27, Volume: 282, Issue:17
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's4 (40.00)18.2507
2000's4 (40.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.48 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.87 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
purine
1H-purine : The 1H-tautomer of purine.. 3H-purine : The 3H-tautomer of purine.. 9H-purine : The 9H-tautomer of purine.. 7H-purine : The 7H-tautomer of purine.		2.0210purine
xanthine
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.. 9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.		210xanthineSaccharomyces cerevisiae metabolite
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.		210adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
aminoimidazole carboxamide
Aminoimidazole Carboxamide: An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.. 5-aminoimidazole-4-carboxamide : An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.		3.2460aminoimidazole;
monocarboxylic acid amide		mouse metabolite
acadesine
[no description available]		1.98101-ribosylimidazolecarboxamide;
aminoimidazole;
nucleoside analogue		antineoplastic agent;
platelet aggregation inhibitor
aica ribonucleotide
AICA ribonucleotide: purine precursor that has antineoplastic activity. AICA ribonucleotide : A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.		3.38701-(phosphoribosyl)imidazolecarboxamide;
aminoimidazole		cardiovascular drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
xanthosine 5'-triphosphate
xanthosine 5'-phosphate : xanthosine phosphate compounds having phosphate groups at position 5'.. 5'-xanthylic acid : A purine ribonucleoside 5'-monophosphate having xanthine as the nucleobase.		210purine ribonucleoside 5'-monophosphate;
xanthosine 5'-phosphate		Escherichia coli metabolite;
metabolite;
mouse metabolite
saicar
SAICAR: adenosylsuccinase catalyzes its conversion to AICAR. SAICAR : A 1-(phosphoribosyl)imidazolecarboxamide resulting from the formal condesation of the darboxy group of 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid with the amino group of L-aspartic acid.		1.97101-(phosphoribosyl)imidazolecarboxamideEscherichia coli metabolite;
mouse metabolite
aminoimidazole ribotide
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole : A 1-(phosphoribosyl)imidazole that is 5-aminoimidazole in which the proton at position 1 has been replaced by a 5-phospho-beta-D-ribofuranosyl group.		1.97101-(phosphoribosyl)imidazole;
aminoimidazole		bacterial metabolite
inosinic acid
Inosine Monophosphate: Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.		2.3920inosine phosphate;
purine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
lometrexol
lometrexol: RN & structure given in first source;		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9810
Leukemia L 1210
[description not available]		01.9710