aryl sulfotransferase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. [EC:2.8.2.1]
Aryl sulfotransferase activity involves the transfer of a sulfonate group (SO3-) from a donor molecule, typically 3'-phosphoadenosine 5'-phosphosulfate (PAPS), to an acceptor molecule that contains an aromatic ring. This transfer reaction is catalyzed by a family of enzymes known as sulfotransferases. The sulfonation of aromatic substrates can have a variety of physiological effects, including:
* **Altering the chemical properties of the substrate:** Sulfonation can increase the water solubility of the substrate, making it easier to excrete. It can also alter the substrate's ability to bind to other molecules, such as proteins or DNA.
* **Modulating the activity of signaling molecules:** Sulfonation can activate or inhibit the activity of certain signaling molecules, such as hormones or neurotransmitters.
* **Detoxification of xenobiotics:** Sulfonation can help to detoxify foreign compounds, such as drugs and environmental toxins, by converting them into more readily excretable forms.
* **Regulation of gene expression:** Sulfonation can play a role in the regulation of gene expression by affecting the binding of transcription factors to DNA.
The specific molecular function of aryl sulfotransferase activity depends on the identity of the substrate and the enzyme involved. For example, some aryl sulfotransferases are involved in the metabolism of steroids, while others are involved in the detoxification of drugs. The diversity of substrates and the wide range of physiological processes that are regulated by sulfonation highlight the importance of this enzymatic activity.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Sulfotransferase 1E1 | A sulfotransferase 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49888] | Homo sapiens (human) |
| Sulfotransferase 1A1 | A sulfotransferase 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50225] | Homo sapiens (human) |
Compounds (10)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| amoxapine | amoxapine : A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position. Amoxapine: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression. | dibenzooxazepine | adrenergic uptake inhibitor; antidepressant; dopaminergic antagonist; geroprotector; serotonin uptake inhibitor |
| protriptyline | Protriptyline: Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation. | carbotricyclic compound | antidepressant |
| ethinyl estradiol | 17alpha-ethynylestradiol : A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. | 17-hydroxy steroid; 3-hydroxy steroid; terminal acetylenic compound | xenoestrogen |
| 2-naphthol | 2-naphthol : A naphthol carrying a hydroxy group at position 2. 2-naphthol: RN given refers to parent cpd naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent. | naphthol | antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger |
| 5-hydroxyindole | hydroxyindoles | human metabolite | |
| 6-hydroxybenzothiazole | |||
| 6-hydroxyindole | 6-hydroxyindole: structure in first source | ||
| 4-hydroxytoremifene | 4-hydroxytoremifene: metabolite of toremifene; RN refers to (Z)-isomer; structure in first source | ||
| 5-hydroxybenzimidazole | 5-hydroxybenzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole carrying a single hydroxy substituent at position 5. 5-hydroxybenzimidazole: only base detected in cobamide cpds from methanol-grown Methanosarcina barkeri | benzimidazoles; phenols | bacterial metabolite; human metabolite; rat metabolite |
| 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole |