Set1C/COMPASS complex
Definition
Target type: cellularcomponent
A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]
The Set1C/COMPASS complex is a multi-protein complex that plays a critical role in histone methylation. Its cellular component is intricately involved in various cellular processes, including DNA replication, transcription, and DNA repair. The complex is localized to the nucleus, specifically associated with chromatin, the complex of DNA and proteins that makes up chromosomes. It consists of several subunits, each contributing to its overall function: \\n\\n* **Set1:** The catalytic subunit responsible for the methylation of histone H3 at lysine 4 (H3K4). This methylation is essential for transcriptional activation, and Set1's activity is tightly regulated by other subunits within the complex. \\n* **Cps30/Shp1/Spp1:** This subunit functions as a scaffold, holding the complex together and facilitating interactions with other proteins. It also directly interacts with histone H3, contributing to the complex's targeting to specific regions of chromatin. \\n* **Cps60:** This subunit is crucial for the complex's interaction with RNA polymerase II (RNAPII), the enzyme responsible for transcribing DNA into RNA. This interaction allows the Set1C/COMPASS complex to be recruited to actively transcribed regions of DNA, enabling efficient H3K4 methylation. \\n* **Cps50/Spp2:** This subunit facilitates the interaction between the complex and the transcription factor Spt5, which plays a role in regulating transcription elongation. This interaction further reinforces the complex's connection to active transcription and ensures efficient H3K4 methylation. \\n* **Cps100/Spp3:** This subunit enhances the catalytic activity of Set1 and is responsible for binding to the N-terminal tail of histone H3. This interaction promotes the efficient methylation of H3K4 by positioning the histone tail correctly for Set1's activity. \\n* **Swd1:** This subunit is involved in the recruitment of the complex to specific regions of chromatin. It directly interacts with the histone H3 tail and helps target the complex to actively transcribed regions. \\n* **Swd2:** This subunit contributes to the stability of the complex and helps ensure the proper localization of the complex to chromatin. \\n* **Swd3:** This subunit plays a role in the complex's interaction with other chromatin-modifying complexes, such as the NuA3 complex. This interaction ensures coordinated regulation of chromatin structure and function. \\n\\nThe Set1C/COMPASS complex's cellular component is crucial for maintaining the proper structure and function of chromatin, ensuring efficient transcription and other essential cellular processes.'
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Proteins (4)
| Protein | Definition | Taxonomy |
|---|---|---|
| Set1/Ash2 histone methyltransferase complex subunit ASH2 | A Set1/Ash2 histone methyltransferase complex subunit ASH2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBL3] | Homo sapiens (human) |
| Protein dpy-30 homolog | A protein dpy-30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C005] | Homo sapiens (human) |
| Retinoblastoma-binding protein 5 | A retinoblastoma-binding protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15291] | Homo sapiens (human) |
| WD repeat-containing protein 5 | A WD repeat-containing protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61964] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| lansoprazole | Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers. | benzimidazoles; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor |
| omeprazole | 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5. omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole. Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. | aromatic ether; benzimidazoles; pyridines; sulfoxide | |
| rabeprazole | Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. | benzimidazoles; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor |
| s-adenosylhomocysteine | S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine. S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. | adenosines; amino acid zwitterion; homocysteine derivative; homocysteines; organic sulfide | cofactor; EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor; EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor; epitope; fundamental metabolite |
| dexlansoprazole | Dexlansoprazole: The R-isomer of lansoprazole that is used to treat severe GASTROESOPHAGEAL REFLUX DISEASE. | benzimidazoles; sulfoxide | |
| oicr-9429 | OICR-9429: antineoplastic; structure in first source |