Page last updated: 2024-10-24

organelle inner membrane

Definition

Target type: cellularcomponent

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. [GOC:mah]

The organelle inner membrane is a specialized membrane that encloses the internal compartment of an organelle. It plays a crucial role in maintaining the organelle's unique environment and facilitating specific functions. This membrane is typically composed of a phospholipid bilayer, with embedded proteins that perform a variety of tasks. The inner membrane of mitochondria, for example, contains proteins involved in electron transport and ATP synthesis. In chloroplasts, the inner membrane harbors proteins responsible for photosynthesis. The specific composition and function of the inner membrane vary depending on the organelle. However, in general, the inner membrane acts as a selective barrier, regulating the passage of molecules into and out of the organelle. It also provides a platform for anchoring enzymes and other proteins involved in organelle-specific processes. The inner membrane is a dynamic structure, constantly undergoing changes in response to cellular signals and environmental cues.'
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Proteins (1)

ProteinDefinitionTaxonomy
Sialidase-4A sialidase-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WWR8]Homo sapiens (human)

Compounds (7)

CompoundDefinitionClassesRoles
zanamivirZanamivir: A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.guanidinesantiviral agent;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
oseltamiviroseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.

Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.
acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound
antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
2-deoxy-2,3-dehydro-n-acetylneuraminic acid2-deoxy-2,3-dehydro-N-acetylneuraminic acid : N-Acetylneuraminic acid reduced across the 2,3-bond with loss of the hydroxy group at C-2; it is a minor component of body fluids although abundant in sialuria.

2-deoxy-2,3-dehydro-N-acetylneuraminic acid: also known as NeuAc2en, but this is also synonym for another compound
N-acetylneuraminic acids
bcx 18123-hydroxy monocarboxylic acid;
acetamides;
cyclopentanols;
guanidines
antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
n-acetylneuraminic acidN-acetylneuraminic acid : An N-acylneuraminic acid where the N-acyl group is specified as acetyl.

N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
N-acetylneuraminic acidsantioxidant;
bacterial metabolite;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
human metabolite;
mouse metabolite
n-acetylneuraminic acidN-acetyl-beta-neuraminic acid : N-Acetylneuraminic acid with beta configuration at the anomeric centre.N-acetylneuraminic acidepitope
4-amino-2-deoxy-2,3-didehydro-n-acetylneuraminic acid