Page last updated: 2024-10-24

RSC-type complex

Definition

Target type: cellularcomponent

A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231]

The RSC-type complex is a large, multi-protein complex that plays a critical role in chromatin remodeling. It is composed of several subunits, each with its own unique function. The core of the RSC complex is formed by the ATPase subunit SNF2h, also known as BRG1. SNF2h is a member of the SWI/SNF family of ATP-dependent chromatin remodelers and is responsible for providing the energy required for chromatin remodeling. The SNF2h subunit interacts with a variety of other subunits, including the SWI/SNF-associated proteins (SWI/SNF-AP) such as SNF5 and BAF57, which contribute to the overall stability of the complex. In addition to these core subunits, the RSC complex also contains a number of other subunits that are involved in specific functions. For example, the RSC complex includes subunits that interact with histone modifications, allowing it to target specific regions of the genome. These subunits can also interact with other proteins, such as transcription factors, to regulate gene expression. The RSC complex is a highly dynamic structure that can be assembled and disassembled in response to various cellular signals. This flexibility allows the RSC complex to adapt to different cellular needs and regulate a wide range of cellular processes, including DNA replication, transcription, and repair.'
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Proteins (4)

ProteinDefinitionTaxonomy
Polycomb protein SUZ12A polycomb protein SUZ12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15022]Homo sapiens (human)
Bromodomain-containing protein 7A bromodomain-containing protein 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPI1]Homo sapiens (human)
Protein polybromo-1A protein polybromo-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86U86]Homo sapiens (human)
Transcription activator BRG1A transcription activator BRG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51532]Homo sapiens (human)

Compounds (16)

CompoundDefinitionClassesRoles
lobenzaritlobenzarit: prevents autoimmune kidney disease in hybrid mice; RN given refers to parent cpdaminobenzoic acid
3-acetylindole3-acetylindole: structure in first source
tanshinonetanshinone: from root of Salvia miltiorrhiza Bunge; RN given refers to tanshinone I; cardioprotective agent and neuroprotective agentabietane diterpenoidanticoronaviral agent
przewaquinone dprzewaquinone D: isolated from root of Salvia przewalskii; structure given in first source; RN given refers to the trans- isomer, przewaquinone D
tanshinone ii atashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first sourceabietane diterpenoid
tg 003TG 003: a Clk inhibitor; structure in first source
2,4-Di(3-pyridyl)-1,3-thiazolethiazoles
5-Methyl-6-(2-thienyl)-2,3,4,5-tetrahydropyridazin-3-onepyridazines
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
su 11248monocarboxylic acid amide;
pyrroles
angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
immunomodulator;
neuroprotective agent;
vascular endothelial growth factor receptor antagonist
i-bet726
epz-6438tazemetostat: a histone methyltransferase EZH2 inhibitor with antineoplastic activity
gsk-2816126GSK-2816126: inhibits EZH2 methyltransferase; structure in first sourcepiperazines;
pyridines
gsk343GSK343 : A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM).

GSK343: an EZH2 methyltransferase inhibitor
aminopyridine;
indazoles;
N-alkylpiperazine;
N-arylpiperazine;
pyridone;
secondary carboxamide
antineoplastic agent;
apoptosis inducer;
EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor
pf-06687252PF-06687252: a SMARCA2/4 bromodomain inhibitor; structure in first source

PFI-3 : An azabicycloalkane that is (1R,4R)-2,5-diazabicyclo[2.2.1]heptane which is substituted at position 2 by a 3-(2-hydroxyphenyl)-3-oxoprop-1-en-1-yl group and at position 5 by a pyridin-2-yl group. It is a potent and selective inhibitor of polybromo 1 (Kd = 48 nM), SMARCA2 and SMARCA4 (Kd = 89 nM) bromodomains.
azabicycloalkane;
enone;
phenols;
pyridines
pf-477736PF 00477736: a Chk1 inhibitor; structure in first source

PF-00477736 : A diazepinoindole that is 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one which is substituted at position 2 by a 1-methylpyrazol-4-yl group and in which the amino group at position 8 has undergone condensation with the carboxy group of (2R)-2-cyclohexylglycine to give the corresponding carboxamide. It is an inhibitor of checkpoint kinase 1 (Chk 1).