guanylate cyclase complex, soluble

Definition

Target type: cellularcomponent

Complex that possesses guanylate cyclase activity and is not bound to a membrane. [GOC:mah]

The guanylate cyclase complex, soluble, is a multi-protein assembly that catalyzes the conversion of GTP to cyclic GMP (cGMP) in the cytosol. This complex is typically found in a soluble form, meaning it is not associated with membranes. The exact composition of the complex can vary depending on the cell type and species, but it often includes a guanylate cyclase catalytic subunit, which is responsible for the enzymatic activity, and a variety of regulatory proteins that control the activity of the complex. These regulatory proteins can include proteins that bind to calcium, calmodulin, or other signaling molecules. The soluble guanylate cyclase complex plays an important role in a wide range of cellular processes, including signal transduction, gene expression, and cell growth. It is particularly important in the regulation of smooth muscle relaxation, and it is also involved in the response to nitric oxide (NO). The soluble guanylate cyclase complex is activated by NO, which binds to the heme group of the catalytic subunit and stimulates its activity. This activation leads to an increase in intracellular cGMP levels, which can then activate downstream signaling pathways. In summary, the soluble guanylate cyclase complex is a complex and dynamic signaling molecule that plays an important role in a variety of cellular processes.'
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Proteins (4)

Compounds (5)