positive regulation of CD8-positive, alpha-beta T cell extravasation

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. [GOC:obol]

Positive regulation of CD8-positive, alpha-beta T cell extravasation is a complex process involving a series of molecular events that enable these cells to exit the bloodstream and migrate to target tissues. It is crucial for effective immune responses, particularly in the context of fighting viral and intracellular bacterial infections. Here's a detailed breakdown:

1. **Chemokine Signaling:**
- CD8+ T cells express chemokine receptors, such as CCR5 and CXCR3, which are activated by chemokines like CCL5 (RANTES) and CXCL10 (IP-10). These chemokines are produced by cells at the site of infection or inflammation and act as chemoattractants, guiding T cells towards the target tissue.

2. **Adhesion Molecule Engagement:**
- Upon arrival at the target site, CD8+ T cells encounter endothelial cells lining blood vessels. These endothelial cells express adhesion molecules, such as ICAM-1 and VCAM-1.
- CD8+ T cells also express counter-receptors, namely LFA-1 and VLA-4, respectively. The interaction between these molecules initiates a tight binding between T cells and the vascular endothelium, promoting their slow rolling along the vessel wall.

3. **Signal Transduction and Diapedesis:**
- The chemokine and adhesion molecule interactions activate intracellular signaling pathways in CD8+ T cells.
- These pathways lead to the rearrangement of the cytoskeleton, formation of lamellipodia, and the expression of additional adhesion molecules. This process ultimately triggers diapedesis, the process by which T cells squeeze through gaps between endothelial cells to enter the surrounding tissue.

4. **Migration within the Tissue:**
- Once in the tissue, CD8+ T cells are guided by the chemokine gradient and other factors, such as antigen presentation by dendritic cells, to reach the site of infection.

5. **Immune Function:**
- At the target site, CD8+ T cells can exert their cytotoxic function, eliminating infected cells or cells expressing tumor-associated antigens.

This intricate process ensures that CD8+ T cells, essential players in adaptive immunity, are effectively recruited to the correct locations to mount a targeted immune response. The fine-tuning of this process, involving chemokines, adhesion molecules, and signaling pathways, is vital for maintaining immune homeostasis and preventing excessive inflammation.'
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Proteins (1)

Compounds (19)