negative regulation of cell motility

Definition

Target type: biologicalprocess

Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. [GOC:mah]

Negative regulation of cell motility is a fundamental biological process that controls the movement of cells. It ensures that cells move in a coordinated and controlled manner, preventing uncontrolled migration that can lead to various pathologies. This process involves a complex interplay of signaling pathways, cytoskeletal dynamics, and adhesive interactions. Key mechanisms include:

1. **Inhibition of signaling pathways:** Signaling pathways, such as the Rho GTPase signaling pathway, are crucial for cell motility. Negative regulation involves the downregulation of these pathways, either by inhibiting upstream activators or by promoting the activity of downstream inhibitors.

2. **Regulation of cytoskeletal dynamics:** The cytoskeleton provides the structural framework for cell movement. Negative regulation can involve the disassembly of actin filaments, which are essential for cell protrusion and migration. Additionally, the stabilization of microtubules, which can act as tracks for organelle transport and cell polarization, can be inhibited.

3. **Modulation of cell-cell and cell-matrix adhesions:** Cell-cell and cell-matrix adhesions are crucial for cell movement and positioning. Negative regulation can involve the detachment of cells from their surroundings, preventing further migration. This can be achieved through the downregulation of adhesion molecules or by promoting the activity of adhesion-degrading enzymes.

4. **Induction of cell cycle arrest:** In some cases, negative regulation of cell motility can be coupled with cell cycle arrest, preventing cell proliferation and further migration.

Overall, negative regulation of cell motility is a complex and tightly controlled process involving multiple signaling pathways, cytoskeletal dynamics, and adhesive interactions. This process plays a crucial role in maintaining tissue integrity, controlling cell migration during development and wound healing, and preventing the spread of cancer cells.'
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Proteins (1)

Compounds (8)