response to resveratrol

Definition

Target type: biologicalprocess

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]

Resveratrol, a naturally occurring polyphenol found in grapes and other plants, elicits a multifaceted response in biological systems. Its diverse effects stem from its ability to modulate various signaling pathways, including those involved in inflammation, oxidative stress, and apoptosis.

Upon entry into the cell, resveratrol interacts with a variety of targets, including sirtuins, which are NAD+-dependent deacetylases that play a crucial role in regulating cellular processes, such as metabolism, stress response, and longevity. Activation of sirtuins by resveratrol has been shown to promote mitochondrial biogenesis and enhance cellular energy production.

Furthermore, resveratrol exhibits antioxidant properties by scavenging free radicals and inhibiting the production of reactive oxygen species (ROS), which can damage cellular components. It also possesses anti-inflammatory effects by suppressing the production of pro-inflammatory cytokines and chemokines.

Resveratrol's impact on cell survival and proliferation is intricate, and its effects can vary depending on cell type and context. In some instances, it promotes apoptosis in cancer cells, while in others, it exhibits cytoprotective effects and enhances cell survival.

The precise mechanisms underlying resveratrol's biological effects are still being investigated, but its multifaceted actions suggest potential therapeutic benefits in a range of conditions, including cancer, cardiovascular disease, and neurodegenerative disorders. However, further research is required to fully elucidate its efficacy and safety in human populations.'
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Proteins (2)

Compounds (17)