Target type: biologicalprocess
Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney. [GOC:dph, GOC:mtg_kidney_jan10]
Kidney morphogenesis, the intricate process of shaping the kidney, relies on a tightly regulated interplay of cell proliferation, differentiation, and apoptosis. Cell proliferation is critical for generating the diverse cell types and expanding the organ's size. Precise regulation of cell division is essential to ensure proper organ formation and function. Multiple signaling pathways, including the Wnt, FGF, and TGF-beta pathways, orchestrate this intricate process.
The Wnt pathway, known for its role in embryonic development, plays a crucial role in kidney morphogenesis by influencing cell proliferation, survival, and differentiation. Wnt signaling initiates a cascade of events leading to the activation of transcription factors, which regulate gene expression and ultimately determine cell fate.
Fibroblast growth factors (FGFs) are another critical player in kidney development, promoting both cell proliferation and differentiation. FGF signaling activates downstream pathways that control cell cycle progression and influence the expression of genes involved in cell growth and development.
Transforming growth factor-beta (TGF-beta) signaling is involved in a multitude of developmental processes, including cell proliferation, differentiation, and apoptosis. In kidney morphogenesis, TGF-beta signaling helps to fine-tune cell proliferation rates and contributes to the formation of various kidney structures.
These signaling pathways act in concert to regulate cell proliferation, ensuring the precise and controlled expansion of kidney tissues. In addition to these major pathways, a multitude of other growth factors, transcription factors, and cell-cell interactions contribute to the complex process of kidney morphogenesis. Dysregulation of these pathways can lead to kidney malformations and diseases, highlighting the critical importance of proper cell proliferation control in kidney development.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | A protein phosphatase 3 catalytic subunit alpha that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q08209] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tacrolimus | tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. | macrolide lactam | bacterial metabolite; immunosuppressive agent |
| tamoxifen | stilbenoid; tertiary amino compound | angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator | |
| cyclosporine | ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF | homodetic cyclic peptide | anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite |